KX2-391

Base Information

• Chemical Name: KX2-391
• CAS No.: 1038395-65-1
• Molecular Formula: C₂₆H₂₉N₃O₃*2ClH
• Molecular Weight: 504.456
• Mol file: 1038395-65-1.mol

Synonyms:KX2-391 dihydrochloride;CS-0455;

Chemical Property of KX2-391

Chemical Property:

• PSA: 67.18000
• LogP: 5.70070

Purity/Quality:

97% ^*data from raw suppliers

KX2-391dihydrochloride >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: KX2-391 is a Src Inhibitor with efficacy against certain hepatic and leukemia cell lines.

Technology Process of KX2-391

There total 5 articles about KX2-391 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-4-(2-morpholinoethoxy)benzene (836-59-9) → 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide dihydrochloride (1038395-65-1)

Guidance literature:

Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water

2: sodium hexamethyldisilazane / Cooling with ice

3: sulfuric acid

4: methoxybenzene / Heating

5: acetyl chloride / ethanol

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; sodium hexamethyldisilazane; sodium carbonate; methoxybenzene; acetyl chloride; In 1,2-dimethoxyethane; ethanol; water; 1: |Suzuki Coupling;

Reference yield:

4-(2-(4-(6-fluoropyridin-3-yl)phenoxy)ethyl)morpholine (1038395-62-8) → 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide dihydrochloride (1038395-65-1)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hexamethyldisilazane / Cooling with ice

2: sulfuric acid

3: methoxybenzene / Heating

4: acetyl chloride / ethanol

With sulfuric acid; sodium hexamethyldisilazane; methoxybenzene; acetyl chloride; In ethanol;

Reference yield:

methyl 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)acetate (1038395-64-0) → 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide dihydrochloride (1038395-65-1)

Guidance literature:

Multi-step reaction with 2 steps

1: methoxybenzene / Heating

2: acetyl chloride / ethanol

With methoxybenzene; acetyl chloride; In ethanol;

upstream raw materials:

4-bromo-phenol

1-bromo-4-(2-morpholinoethoxy)benzene

4-(2-(4-(6-fluoropyridin-3-yl)phenoxy)ethyl)morpholine

2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)acetonitrile

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