N-Cyclobutylmethylmorphinan-6-one

Base Information

Chemical Name:N-Cyclobutylmethylmorphinan-6-one
CAS No.:127322-13-8
Molecular Formula:C₂₁H₂₇NO
Molecular Weight:309.451
Hs Code.:
DSSTox Substance ID:DTXSID20925862
Wikidata:Q82900283

Synonyms:N-Cyclobutylmethylmorphinan-6-one;Morphinan-6-one, 17-(cyclobutylmethyl)-;127322-13-8;17-(Cyclobutylmethyl)morphinan-6-one;DTXSID20925862

Suppliers and Price of N-Cyclobutylmethylmorphinan-6-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of N-Cyclobutylmethylmorphinan-6-one

Chemical Property:

Vapor Pressure:1.07E-08mmHg at 25°C
XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:309.209264485
Heavy Atom Count:23
Complexity:484

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC(C1)CN2CCC34CC(=O)CCC3C2CC5=CC=CC=C45
Isomeric SMILES:C1CC(C1)CN2CC[C@]34CC(=O)CC[C@H]3[C@H]2CC5=CC=CC=C45

Technology Process of N-Cyclobutylmethylmorphinan-6-one

There total 7 articles about N-Cyclobutylmethylmorphinan-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 127322-10-5,127322-18-3
C₂₁H₂₉NO

: 127322-13-8
(-)-17-Cyclobutylmethylmorphinan-6-one

Guidance literature:: With benzophenone; potassium tert-butylate; In toluene; at 90 ℃; for 3h;
DOI:10.1002/ardp.19903230108

Reference yield:

: 81451-64-1
(-)-N-methylmorphinan-6-one

: 127322-13-8
(-)-17-Cyclobutylmethylmorphinan-6-one

Guidance literature:: Multi-step reaction with 6 steps

1: 2.78 g / 1,2-dichloro-ethane / 60 h / 60 - 65 °C

2: HCl / CH₂Cl₂ / Ambient temperature

3: methanol / 1 h / Heating

4: 730 mg / K₂CO₃ / CH₂Cl₂ / 2 h / Heating

5: 630 mg / LiAlH₄ / diethyl ether; CH₂Cl₂ / 1 h / Heating

6: 490 mg / benzophenone, t-BuOK / toluene / 3 h / 90 °C

With hydrogenchloride; lithium aluminium tetrahydride; benzophenone; potassium tert-butylate; potassium carbonate; In methanol; diethyl ether; dichloromethane; 1,2-dichloro-ethane; toluene;
DOI:10.1002/ardp.19903230108

Reference yield:

: 127322-15-0
C₁₉H₂₁NO₃

: 127322-13-8
(-)-17-Cyclobutylmethylmorphinan-6-one

Guidance literature:: Multi-step reaction with 5 steps

1: HCl / CH₂Cl₂ / Ambient temperature

2: methanol / 1 h / Heating

3: 730 mg / K₂CO₃ / CH₂Cl₂ / 2 h / Heating

4: 630 mg / LiAlH₄ / diethyl ether; CH₂Cl₂ / 1 h / Heating

5: 490 mg / benzophenone, t-BuOK / toluene / 3 h / 90 °C

With hydrogenchloride; lithium aluminium tetrahydride; benzophenone; potassium tert-butylate; potassium carbonate; In methanol; diethyl ether; dichloromethane; toluene;
DOI:10.1002/ardp.19903230108