2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]-9H-purin-2-yl]amino]-1-butanoldihydrochloride

Base Information

Chemical Name:2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]-9H-purin-2-yl]amino]-1-butanoldihydrochloride
CAS No.:1056016-06-8
Molecular Formula:C23H29Cl2N7O
Molecular Weight:417.514
Hs Code.:
Mol file:1056016-06-8.mol

Synonyms:(R)-DRF053 dihydrochloride;2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]-9H-purin-2-yl]amino]-1-butanoldihydrochloride;(R)-DRF053;1-Butanol, 2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]aMino]-9H-purin-2-yl]aMino]-, (2R)-

Suppliers and Price of 2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]-9H-purin-2-yl]amino]-1-butanoldihydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Tocris
(R)-DRF053dihydrochloride ≥98%(HPLC)
50
$ 1070.00

Tocris
(R)-DRF053dihydrochloride ≥98%(HPLC)
10
$ 249.00

Matrix Scientific
(R)-2-((9-Isopropyl-6-((3-(pyridin-2-yl)phenyl)-amino)-9H-purin-2-yl)amino)butan-1-ol 95+%
1g
$ 1647.00

Matrix Scientific
(R)-2-((9-Isopropyl-6-((3-(pyridin-2-yl)phenyl)-amino)-9H-purin-2-yl)amino)butan-1-ol 95+%
250mg
$ 742.00

American Custom Chemicals Corporation
(2R)-2-[[9-(1-METHYLETHYL)-6-[[3-(2-PYRIDINYL)PHENYL]AMINO]-9H-PURIN-2-YL]AMINO]-1-BUTANOL 95.00%
5MG
$ 505.02

AK Scientific
(R)-2-((9-Isopropyl-6-((3-(pyridin-2-yl)phenyl)amino)-9H-purin-2-yl)amino)butan-1-ol
1g
$ 2273.00

AK Scientific
(R)-2-((9-Isopropyl-6-((3-(pyridin-2-yl)phenyl)amino)-9H-purin-2-yl)amino)butan-1-ol
250mg
$ 1051.00

Total 19 raw suppliers

Chemical Property of 2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]-9H-purin-2-yl]amino]-1-butanoldihydrochloride

Chemical Property:

PSA：100.78000
LogP:4.54160
Storage Temp.:Store at +4°C

Purity/Quality:

97% ^*data from raw suppliers

(R)-DRF053dihydrochloride ≥98%(HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]-9H-purin-2-yl]amino]-1-butanoldihydrochloride

There total 5 articles about 2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]-9H-purin-2-yl]amino]-1-butanoldihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 5856-63-3
(2R)-2-aminobutan-1-ol

: 1056016-04-6
2-chloro-6-[3-(2-pyridyl)phenylamino]-9-iso-propylpurine

: 1056016-06-8
DRF 053

Guidance literature:: With tributyl-amine; In dimethyl sulfoxide; at 165 ℃; for 3h;
DOI:10.1021/jm800109e

Reference yield:

: 1008-89-5
2-phenylpyridine

: 1056016-06-8
DRF 053

Guidance literature:: Multi-step reaction with 4 steps

1: silver trifluoroacetate; tetrabutylammonium acetate; dodecacarbonyl-triangulo-triruthenium; copper(II) nitrate trihydrate; oxone||potassium monopersulfate triple salt / 1,2-dichloro-ethane / 24 h / 95 °C / Sealed tube

2: palladium on activated charcoal; hydrogen / methanol / 3 h / 40 °C

3: triethylamine / butan-1-ol / 2 h / 100 °C

4: tributyl-amine / dimethyl sulfoxide / 3 h / 165 °C

With dodecacarbonyl-triangulo-triruthenium; copper(II) nitrate trihydrate; tributyl-amine; oxone||potassium monopersulfate triple salt; palladium on activated charcoal; hydrogen; tetrabutylammonium acetate; silver trifluoroacetate; triethylamine; In methanol; dimethyl sulfoxide; 1,2-dichloro-ethane; butan-1-ol;
DOI:10.1021/jacs.6b03402

Reference yield:

: C₂₄H₁₆N₂O₂Ru

: 1056016-06-8
DRF 053

Guidance literature:: Multi-step reaction with 4 steps

1: silver trifluoroacetate; tetrabutylammonium acetate; copper(II) nitrate trihydrate; oxone||potassium monopersulfate triple salt / 1,2-dichloro-ethane / 24 h / 95 °C / Sealed tube

2: palladium on activated charcoal; hydrogen / methanol / 3 h / 40 °C

3: triethylamine / butan-1-ol / 2 h / 100 °C

4: tributyl-amine / dimethyl sulfoxide / 3 h / 165 °C

With copper(II) nitrate trihydrate; tributyl-amine; oxone||potassium monopersulfate triple salt; palladium on activated charcoal; hydrogen; tetrabutylammonium acetate; silver trifluoroacetate; triethylamine; In methanol; dimethyl sulfoxide; 1,2-dichloro-ethane; butan-1-ol;
DOI:10.1021/jacs.6b03402