Chemical Property of 2'-deoxy-2'-fluoro-2'-C-methylcytidine
Chemical Property:
- Appearance/Colour:Pale brown solid
- Melting Point:216-218℃
- Boiling Point:482.4±55.0 °C(Predicted)
- PKA:12.86±0.70(Predicted)
- PSA：110.60000
- Density:1.67
- LogP:-0.61450
- Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
- Solubility.:Methanol (Slightly), Water (Slightly)
- XLogP3:-1.4
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:2
- Exact Mass:259.09683410
- Heavy Atom Count:18
- Complexity:427
- Purity/Quality:
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99%, *data from raw suppliers
PSI6130 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1(C(C(OC1N2C=CC(=NC2=O)N)CO)O)F
- Isomeric SMILES:C[C@]1([C@@H]([C@H](O[C@H]1N2C=CC(=NC2=O)N)CO)O)F
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Description
PSI-6130 is a nucleoside inhibitor of the NS5B RNA polymerase of hepatitis C virus (HCV; Ki = 4.3 μM). It inhibits HCV genotype 1b (GT-1b) Con1 and GT-1a H77 viral replication in Huh7 replicon cells using a luciferase-based assay (EC50s = 0.51 and 0.30 μM, respectively). PSI-6130 also inhibits replication of HCV GT-1b and GT-1a replicons from clinical isolates, with EC50 values ranging from 0.60 to 1.41 μM, and 0.20 to 0.43 μM, respectively, in the same assay. It has little or no activity against West Nile Virus (WNV), Dengue type 2 virus (DV), human immunodeficiency virus (HIV), or hepatitis B virus (HBV; EC90s = 46.3, >100, >100, and >10 μM, respectively).
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Uses
PSI-6130 is an experimental treatment for hepatitis C. PSI-6130 is a member of a class of antiviral drugs known as nucleoside polymerase inhibitors. PSI-6130 inhibits the hepatitis C virus RNA dependant RNA polymerase called NS5B.
