NLS-96184

Base Information

Chemical Name:NLS-96184
CAS No.:256954-97-9
Molecular Formula:C27H39FN4O4S
Molecular Weight:534.695
Hs Code.:
Mol file:256954-97-9.mol

Synonyms:NLS-96184;XEMTYGFOVBXDLG-JOCHJYFZSA-N;4-Piperidineacetic acid, 1-[(3R)-3-[[2-fluoro-4-(iMino-3-thiazolidinylMethyl)benzoyl]aMino]-2,2-diMethyl-1-oxopentyl]-, ethyl ester

Suppliers and Price of NLS-96184

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of NLS-96184

Chemical Property:

PSA：128.10000
LogP:4.25020

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of NLS-96184

There total 7 articles about NLS-96184 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59184-90-6
ethyl (piperidin-4-yl)acetate

: 256954-97-9
(1-{(R)-3-[2-Fluoro-4-(imino-thiazolidin-3-yl-methyl)-benzoylamino]-2,2-dimethyl-pentanoyl}-piperidin-4-yl)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / HATU, DIEA / CH₂Cl₂ / 18 h / Ambient temperature

2: HOBt, WSCD*HCl / dimethylformamide

3: 1.) H₂S, Et₃N, 2.) MeI

With WSCD*HCl; hydrogen sulfide; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; methyl iodide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980126v

Reference yield:

: 115524-82-8
4-ethyl-3,3-dimethyl-2-azetidinone

: 256954-97-9
(1-{(R)-3-[2-Fluoro-4-(imino-thiazolidin-3-yl-methyl)-benzoylamino]-2,2-dimethyl-pentanoyl}-piperidin-4-yl)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 81 percent / 6N aq. HCl / 24 h / Ambient temperature

2: 98 percent / 10percent aq. Na₂CO₃ / dioxane / Ambient temperature

3: 39 percent / HATU, Et₃N / CH₂Cl₂ / 5 h / Ambient temperature

4: 1.) 6N aq. HCl, 2.) (Boc)2O, 10percent Na₂CO₃ / 1.) reflux, 2.) doxane

5: 91 percent / HATU, DIEA / CH₂Cl₂ / 18 h / Ambient temperature

6: HOBt, WSCD*HCl / dimethylformamide

7: 1.) H₂S, Et₃N, 2.) MeI

With hydrogenchloride; di-tert-butyl dicarbonate; WSCD*HCl; hydrogen sulfide; sodium carbonate; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; methyl iodide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980126v

Reference yield:

: β-Ethyl-α,α-dimethyl-β-alanine hydrochloride

: 256954-97-9
(1-{(R)-3-[2-Fluoro-4-(imino-thiazolidin-3-yl-methyl)-benzoylamino]-2,2-dimethyl-pentanoyl}-piperidin-4-yl)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / 10percent aq. Na₂CO₃ / dioxane / Ambient temperature

2: 39 percent / HATU, Et₃N / CH₂Cl₂ / 5 h / Ambient temperature

3: 1.) 6N aq. HCl, 2.) (Boc)2O, 10percent Na₂CO₃ / 1.) reflux, 2.) doxane

4: 91 percent / HATU, DIEA / CH₂Cl₂ / 18 h / Ambient temperature

5: HOBt, WSCD*HCl / dimethylformamide

6: 1.) H₂S, Et₃N, 2.) MeI

With hydrogenchloride; di-tert-butyl dicarbonate; WSCD*HCl; hydrogen sulfide; sodium carbonate; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; methyl iodide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980126v