Chemical Property of N,N'-[[1,1'-Biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]biscarbamic acid dimethyl ester hydrochloride
Chemical Property:
- PSA：181.62000
- LogP:8.11060
- Storage Temp.:-20°C Freezer
- Solubility.:DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- Purity/Quality:
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99%, *data from raw suppliers
DaclatasvirDihydrochloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
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Description
Daclatasvir dihydrochloride is a hepatitis C virus nonstructural
5A (NS5A) replication complex inhibitor which was first approved
in Japan for the treatment of genotype 1 HCV patients who fail to
respond to interferon plus ribavirin. The drug has also been
approved for patients with untreated, chronic HCV who are eligible for interferon. Additionally, in Europe, daclatasvir was approved for
use in combination with other products across genotype 1–4 HCV.
Daclatasvir was discovered and developed by Bristol–Myers Squibb
and a fascinating account describing the initiation of the program
from a phenotypic screen and the medicinal chemistry strategy
leading to the discovery of the compound has been recently
reported.
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Uses
Daclatasvir Dihydrochloride is the dihydrochloride salt form of daclatasvir, an orally available inhibitor of the hepatitis C virus (HCV) non-structural protein 5A (NS5A) replication complex, with potential activity against HCV. Daclatasvir is used with another antiviral medication (sofosbuvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. Daclatasvir should never be used without sofosbuvir. Daclatasvir and sofosbuvir may also be used with another antiviral medication (ribavirin).
