5-[(2R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-hydroxymethyl-2,5-dihydro-furan-2-yl]-2-(tetrahydro-pyran-2-yl)-2H-pyrazole-3,4-dicarboxylic acid diethyl ester

Base Information

Chemical Name:5-[(2R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-hydroxymethyl-2,5-dihydro-furan-2-yl]-2-(tetrahydro-pyran-2-yl)-2H-pyrazole-3,4-dicarboxylic acid diethyl ester
CAS No.:190263-27-5
Molecular Formula:C₃₅H₄₄N₂O₈Si
Molecular Weight:648.828
Hs Code.:

5-[(2R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-hydroxymethyl-2,5-dihydro-furan-2-yl]-2-(tetrahydro-pyran-2-yl)-2H-pyrazole-3,4-dicarboxylic acid diethyl ester

Synonyms:

Suppliers and Price of 5-[(2R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-hydroxymethyl-2,5-dihydro-furan-2-yl]-2-(tetrahydro-pyran-2-yl)-2H-pyrazole-3,4-dicarboxylic acid diethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-[(2R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-hydroxymethyl-2,5-dihydro-furan-2-yl]-2-(tetrahydro-pyran-2-yl)-2H-pyrazole-3,4-dicarboxylic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-[(2R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-hydroxymethyl-2,5-dihydro-furan-2-yl]-2-(tetrahydro-pyran-2-yl)-2H-pyrazole-3,4-dicarboxylic acid diethyl ester

There total 4 articles about 5-[(2R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-hydroxymethyl-2,5-dihydro-furan-2-yl]-2-(tetrahydro-pyran-2-yl)-2H-pyrazole-3,4-dicarboxylic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 130277-32-6
((2R,3S)-3-(tert-butyldiphenylsilyloxy)-2,3-dihydrofuran-2-yl)methanol

: 190263-25-3
5-Iodo-2-(tetrahydro-pyran-2-yl)-2H-pyrazole-3,4-dicarboxylic acid diethyl ester

: 190263-27-5
5-[(2R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-hydroxymethyl-2,5-dihydro-furan-2-yl]-2-(tetrahydro-pyran-2-yl)-2H-pyrazole-3,4-dicarboxylic acid diethyl ester

Guidance literature:: With triethylamine; tris-(o-tolyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; at 85 ℃; for 15h;
DOI:10.1080/07328319708001352

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 190263-27-5
5-[(2R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-hydroxymethyl-2,5-dihydro-furan-2-yl]-2-(tetrahydro-pyran-2-yl)-2H-pyrazole-3,4-dicarboxylic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / p-toluenesulfonic acid / CCl₄; tetrahydrofuran / 3 h / 0 - 5 °C

2: 71 percent / bis(dibenzylideneacetone)palladium⁽⁰⁾, tri-o-tolylphosphine, triethylamine / 15 h / 85 °C

With toluene-4-sulfonic acid; triethylamine; tris-(o-tolyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; tetrachloromethane;
DOI:10.1080/07328319708001352

Reference yield:

: 37687-26-6
diethyl 1H-pyrazole-4,5-dicarboxylate

: 190263-27-5
5-[(2R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-hydroxymethyl-2,5-dihydro-furan-2-yl]-2-(tetrahydro-pyran-2-yl)-2H-pyrazole-3,4-dicarboxylic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / N-iodosuccinimide / dimethylformamide / 4.5 h / 115 °C

2: 62 percent / p-toluenesulfonic acid / CCl₄; tetrahydrofuran / 3 h / 0 - 5 °C

3: 71 percent / bis(dibenzylideneacetone)palladium⁽⁰⁾, tri-o-tolylphosphine, triethylamine / 15 h / 85 °C

With N-iodo-succinimide; toluene-4-sulfonic acid; triethylamine; tris-(o-tolyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1080/07328319708001352