Dutogliptin

Base Information

Chemical Name:Dutogliptin
CAS No.:852329-66-9
Molecular Formula:C10H20BN3O3
Molecular Weight:241.098
Hs Code.:
UNII:38EAO245ZX
ChEMBL ID:CHEMBL4296719
DSSTox Substance ID:DTXSID301005713
Metabolomics Workbench ID:152833
NCI Thesaurus Code:C87492
Nikkaji Number:J3.333.210F
Pharos Ligand ID:7UYXC9GAJUDR
Mol file:852329-66-9.mol

Synonyms:dutogliptin

Suppliers and Price of Dutogliptin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Dutogliptin 95+%
1g
$ 248.00

Crysdot
Dutogliptin 95+%
5g
$ 743.00

ChemScene
Dutogliptin 99.16%
10mg
$ 1500.00

ChemScene
Dutogliptin 99.16%
5mg
$ 980.00

ChemScene
Dutogliptin 99.16%
1mg
$ 550.00

American Custom Chemicals Corporation
DUTOGLIPTIN 95.00%
5MG
$ 502.63

Total 27 raw suppliers

Chemical Property of Dutogliptin

Chemical Property:

Boiling Point:494.6±55.0 °C(Predicted)
PKA:9.71±0.20(Predicted)
PSA：84.83000
Density:1.24±0.1 g/cm3(Predicted)
LogP:-0.98160
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:241.1597717
Heavy Atom Count:17
Complexity:278

Purity/Quality:

97% ^*data from raw suppliers

Dutogliptin 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:B(C1CCCN1C(=O)CNC2CCNC2)(O)O
Isomeric SMILES:B([C@@H]1CCCN1C(=O)CN[C@@H]2CCNC2)(O)O
Recent ClinicalTrials:Dutogliptin in Co-administration With Filgrastim in Early Recovery Post-myocardial Infarction
Recent EU Clinical Trials:A Phase III, Multicenter, Double-blind, Active-Controlled, 52-Week Extension Study to Evaluate the Safety and Efficacy of Dutogliptin in Patients With Type 2 Diabetes Mellitus Receiving Background Treatment With Glimepiride Alone or in Combination With Metformin or With Pioglitazone Alone

Technology Process of Dutogliptin

There total 4 articles about Dutogliptin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 923566-03-4
(2R)-1-{2-[(3R)-pyrrolidinylamino]-acetyl}-pyrrolidine-2-boronic acid (1S,2S,3R,5S)-pinanediol ester

: 852329-66-9
Dutogliptin

Guidance literature:: With hydrogenchloride; phenylboronic acid; In water; for 24h; pH=2;

Reference yield:

: 1056211-06-3,1184179-07-4
3-(R)-(benzyloxycarbonyl-carboxymethyl-amino)-pyrrolidine-1-carboxylic acid benzyl ester

: 852329-66-9
Dutogliptin

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 25 °C

2: hydrogen; 0.5% Pd/C / methanol / 5 - 30 °C / 2250.23 - 6750.68 Torr

3: hydrogenchloride; phenylboronic acid / water / 24 h / pH 2

With hydrogenchloride; 0.5% Pd/C; hydrogen; N-ethyl-N,N-diisopropylamine; phenylboronic acid; In methanol; dichloromethane; water;

Reference yield:

: (R)-3-(Benzyloxycarbonyl-{2-oxo-2-[(R)-2-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.02,6]dec-4-yl)-pyrrolidin-1-yl]-ethyl}-amino)-pyrrolidine-1-carboxylic acid benzyl ester

: 852329-66-9
Dutogliptin

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; 0.5% Pd/C / methanol / 5 - 30 °C / 2250.23 - 6750.68 Torr

2: hydrogenchloride; phenylboronic acid / water / 24 h / pH 2

With hydrogenchloride; 0.5% Pd/C; hydrogen; phenylboronic acid; In methanol; water;