Pentanamide, N-(1-cyanocyclopropyl)-2-(((1S)-1-(4'-((1R)-2,2-difluoro-1-hydroxyethyl)(1,1'-biphenyl)-4-yl)-2,2,2-trifluoroethyl)amino)-4-fluoro-4-methyl-, (2S)-

Base Information

Chemical Name:Pentanamide, N-(1-cyanocyclopropyl)-2-(((1S)-1-(4'-((1R)-2,2-difluoro-1-hydroxyethyl)(1,1'-biphenyl)-4-yl)-2,2,2-trifluoroethyl)amino)-4-fluoro-4-methyl-, (2S)-
CAS No.:887781-62-6
Molecular Formula:C₂₆H₂₇F₆N₃O₂
Molecular Weight:527.51
Hs Code.:
UNII:51JM065FZ0
ChEMBL ID:CHEMBL603899
Wikidata:Q27260901

Pentanamide, N-(1-cyanocyclopropyl)-2-(((1S)-1-(4'-((1R)-2,2-difluoro-1-hydroxyethyl)(1,1'-biphenyl)-4-yl)-2,2,2-trifluoroethyl)amino)-4-fluoro-4-methyl-, (2S)-

Synonyms:MK 0674;MK-0674;MK0674

Suppliers and Price of Pentanamide, N-(1-cyanocyclopropyl)-2-(((1S)-1-(4'-((1R)-2,2-difluoro-1-hydroxyethyl)(1,1'-biphenyl)-4-yl)-2,2,2-trifluoroethyl)amino)-4-fluoro-4-methyl-, (2S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
MK-0674 95.00%
5MG
$ 501.75

Total 7 raw suppliers

Chemical Property of Pentanamide, N-(1-cyanocyclopropyl)-2-(((1S)-1-(4'-((1R)-2,2-difluoro-1-hydroxyethyl)(1,1'-biphenyl)-4-yl)-2,2,2-trifluoroethyl)amino)-4-fluoro-4-methyl-, (2S)-

Chemical Property:

PSA：85.15000
LogP:6.30608
XLogP3:4.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:10
Exact Mass:527.20074608
Heavy Atom Count:37
Complexity:822

Purity/Quality:

99% ^*data from raw suppliers

MK-0674 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(CC(C(=O)NC1(CC1)C#N)NC(C2=CC=C(C=C2)C3=CC=C(C=C3)C(C(F)F)O)C(F)(F)F)F
Isomeric SMILES:CC(C)(C[C@@H](C(=O)NC1(CC1)C#N)N[C@@H](C2=CC=C(C=C2)C3=CC=C(C=C3)[C@H](C(F)F)O)C(F)(F)F)F

Technology Process of Pentanamide, N-(1-cyanocyclopropyl)-2-(((1S)-1-(4'-((1R)-2,2-difluoro-1-hydroxyethyl)(1,1'-biphenyl)-4-yl)-2,2,2-trifluoroethyl)amino)-4-fluoro-4-methyl-, (2S)-

There total 7 articles about Pentanamide, N-(1-cyanocyclopropyl)-2-(((1S)-1-(4'-((1R)-2,2-difluoro-1-hydroxyethyl)(1,1'-biphenyl)-4-yl)-2,2,2-trifluoroethyl)amino)-4-fluoro-4-methyl-, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 847358-99-0
(S)-N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-(((S)-2,2,2-trifluoro-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)amino)pentanamide

: 887781-84-2
(1R)-1-(4-bromophenyl)-2,2-difluoroethanol

: 887781-62-6
MK-0674

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; at 80 ℃;
DOI:10.1016/j.bmcl.2009.12.083

Reference yield:

: (2S)-2-[[(1S)-1-[4-[4-[(1R)-2,2-difluoro-1-hydroxyethyl]phenyl]phenyl]-2,2,2-trifluoroethyl]amino]-4-fluoro-4-methylpentanoic acid

: 127946-77-4
1-amino-1-cyclopropanecarbonitrile hydrochloride

: 887781-62-6
MK-0674

Guidance literature:: With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 3.5h; Temperature; Reagent/catalyst; Solvent; Large scale;

Reference yield:

: 847358-99-0
(S)-N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-(((S)-2,2,2-trifluoro-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)amino)pentanamide

: 887781-85-3
(S)-1-(4-bromophenyl)-2,2-difluoroethanol

: 887781-62-6
N1-(1-cyanocyclopropyl)-N2-((1S)-1-{4'-[(1S)-2,2-difluoro-1-hydroxyethyl]biphenyl-4-yl}-2,2,2-trifluoroethyl)-4-fluoro-L-leucinamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; at 80 ℃;
DOI:10.1016/j.bmcl.2009.12.083