Chemical Property of 2-Hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid
Chemical Property:
- Boiling Point:654.7 °C at 760 mmHg
- PKA:2.98±0.10(Predicted)
- Flash Point:349.8 °C
- PSA：138.38000
- Density:1.507 g/cm3
- LogP:2.89660
- Storage Temp.:?20°C
- Solubility.:DMSO: >10mg/mL
- XLogP3:3
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:6
- Exact Mass:365.05692299
- Heavy Atom Count:25
- Complexity:578
- Purity/Quality:
-
99%, *data from raw suppliers
NSC 74859 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O
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Uses
A chemical probe inhibitor of STAT3 with an IC50 of 86 μM. S2I-201 is a small molecule inhibitor that provides a pathway to rational combination therapies for Melanoma. S3I-201 has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor: to confirm the role of STAT3 phosphorylation in interleukin (IL)-33 production in lung epithelial cells and IL-22 mRNA expression in sorted group 3 innate lymphoid cells (ILC3s) to study the cellular response of STAT3 triggered by β-hexaclorocyclohexane (β-HCH) in various cell linesto examine the influence of STAT3 in response to angiotensin II (ang II) on induction of fibrotic proteins in kidney epithelial cells
