1-(2-Fluorophenyl)cyclobutanecarboxylic acid

Base Information

• Chemical Name: 1-(2-Fluorophenyl)cyclobutanecarboxylic acid
• CAS No.: 151157-48-1
• Molecular Formula: C11H11FO2
• Molecular Weight: 194.206
• Hs Code.: 2916399090
• Mol file: 151157-48-1.mol

Synonyms: 1-Carboxy-1-(2-fluorophenyl)cyclobutane;1-(2-fluorophenyl)cyclobutanecarboxylic acid;1-(2-Fluorophenyl)cyclobutane-1-carboxylic acid

Chemical Property of 1-(2-Fluorophenyl)cyclobutanecarboxylic acid

Chemical Property:

• Boiling Point: 325.936 °C at 760 mmHg
• Flash Point: 150.921 °C
• PSA: 37.30000
• Density: 1.294 g/cm³
• LogP: 2.33200
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1-(2-Fluorophenyl)cyclobutane-1-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-Fluorophenyl)cyclobutanecarboxylic acid

There total 2 articles about 1-(2-Fluorophenyl)cyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.6%

1-(2-fluorophenyl)cyclobutane-1-carbonitrile (28049-63-0) → 1-(2-Fluorophenyl)cyclobutanecarboxylic Acid (151157-48-1)

Guidance literature:

With potassium hydroxide; In ethanol; water; for 12h; Reflux;

Reference yield:

→ 1-(2-Fluorophenyl)cyclobutanecarboxylic Acid (151157-48-1)

Guidance literature:

Reference yield:

1-(2-Fluorophenyl)cyclobutanecarboxylic Acid (151157-48-1) → 1-(2-fluorophenyl)-cyclobutanecarbohydrazide (1041867-28-0)

Guidance literature:

With triethylamine; hydrazine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.5h;

upstream raw materials:

1-(2-fluorophenyl)cyclobutane-1-carbonitrile

Downstream raw materials:

1-(2-fluorophenyl)-cyclobutanecarbohydrazide

Refernces

• 1、 -. "11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 INHIBITORS USEFUL FOR THE TREATMENT OF DIABETES, OBESITY AND DYSLIPIDEMIA". Page 41. . Retrieved 2010/02/05.