8-Boc-1,8-diazaspiro[4.5]...

Base Information

• Chemical Name: 8-Boc-1,8-diazaspiro[4.5]...
• CAS No.: 937729-06-1
• Molecular Formula: C13H24N2O2
• Molecular Weight: 240.346
• Hs Code.: 2933990090
• Mol file: 937729-06-1.mol

Synonyms:1,8-Diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester;8-Boc-1,8-Diaza-spiro[4.5]decane;

Chemical Property of 8-Boc-1,8-diazaspiro[4.5]...

Chemical Property:

• Boiling Point: 337.0±35.0 °C(Predicted)
• PKA: 10.74±0.20(Predicted)
• PSA: 41.57000
• Density: 1.07±0.1 g/cm3(Predicted)
• LogP: 2.40620
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 1,8-diazaspiro[4.5]decane-8-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Boc-1,8-diazaspiro[4.5]...

There total 1 articles about 8-Boc-1,8-diazaspiro[4.5]... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

di-tert-butyl dicarbonate (24424-99-5) + 1,8-dibenzyl-3-bromo-1,8-diazaspiro[4.5]decane (1100748-76-2) → 1,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester (937729-06-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In isopropyl alcohol; at 75 ℃; for 48h;

DOI:10.1021/jo802456w

Reference yield: 100.0%

1,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester (937729-06-1) + di-t-butoxycarbonyl-L-cystine (10389-65-8) → L-cystinebis(1,8-diazaspiro[4.5]decan-8-yl) tetrahydrochloride

Guidance literature:

1,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester; With (fluorenylmethoxy)carbonyl chloride; sodium carbonate; In 1,4-dioxane; water; at 0 - 20 ℃;

With hydrogenchloride; In 1,4-dioxane; at 0 - 20 ℃; for 1.5h;

di-t-butoxycarbonyl-L-cystine; Further stages;

Reference yield: 92.0%

1,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester (937729-06-1) + 2-thiomorpholino-4-(trifluoromethyl)benzaldehyde → tert-butyl 1-(2-thiomorpholino-4-(trifluoromethyl)benzyl)-1,8-diazaspiro[4.5]decane-8-carboxylate

Guidance literature:

1,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester; 2-thiomorpholino-4-(trifluoromethyl)benzaldehyde; With triethylamine; In 1,2-dichloro-ethane; at 20 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃;

upstream raw materials:

di-tert-butyl dicarbonate

1,8-dibenzyl-3-bromo-1,8-diazaspiro[4.5]decane

Downstream raw materials:

6-(1,8-diazaspiro[4.5]decan-1-yl)-9H-purine

benzyl 8-(9H-purin-6-yl)-1,8-diazaspiro[4.5]decane-1-carboxylate

6-(1,8-diazaspiro[4.5]decan-8-yl)-9H-purine

5-(1,8-diazaspiro[4.5]decan-8-ylsulfonyl)isoquinoline