7-Boc-1,7-diaza-spiro[4.4]nonane

Base Information

• Chemical Name: 7-Boc-1,7-diaza-spiro[4.4]nonane
• CAS No.: 646055-63-2
• Molecular Formula: C12H22N2O2
• Molecular Weight: 226.32
• Hs Code.: 2933990090
• Mol file: 646055-63-2.mol

Synonyms:1,7-DIAZA-SPIRO[4.4]NONANE-7-CARBOXYLIC ACID TERT-BUTYL ESTER;TERT-BUTYL 1,7-DIAZASPIRO[4.4]NONANE-7-CARBOXYLATE;

Chemical Property of 7-Boc-1,7-diaza-spiro[4.4]nonane

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 319.425°C at 760 mmHg
• PKA: 10.72±0.20(Predicted)
• Flash Point: 146.983°C
• PSA: 41.57000
• Density: 1.089g/cm³
• LogP: 2.01610
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

1,7-Diaza-spiro[4.4]nonane-7-carboxylicAcidtert-ButylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Boc-1,7-diaza-spiro[4.4]nonane

There total 3 articles about 7-Boc-1,7-diaza-spiro[4.4]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 6-benzyl-2,6-diazaspiro [4.4]nonane-2-carboxylate (646055-62-1) → t-butyl 1,7-diazaspiro[4.4]nonane-7-carboxylate (646055-63-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; for 8h; under 2585.81 Torr; Parr hydrogenation apparatus;

Reference yield: 45.0%

tert-butyl 3-(2-tosylhydrazono)-pyrrolidine-1-carboxylate (1510865-62-9) + (3-azidopropyl)boronic acid → t-butyl 1,7-diazaspiro[4.4]nonane-7-carboxylate (646055-63-2)

Guidance literature:

With potassium carbonate; In 1,4-dioxane; at 20 - 150 ℃; for 1.16667h; Inert atmosphere; Microwave irradiation; Sealed tube;

DOI:10.1002/anie.202113370

Reference yield:

C18H25N3O6S → t-butyl 1,7-diazaspiro[4.4]nonane-7-carboxylate (646055-63-2)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 12h;

DOI:10.1016/j.bmcl.2019.126748

upstream raw materials:

tert-butyl 6-benzyl-2,6-diazaspiro [4.4]nonane-2-carboxylate

tert-butyl 3-(2-tosylhydrazono)-pyrrolidine-1-carboxylate

Downstream raw materials:

1-methyl-1,7-diazaspiro[4,4]nonane

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