CHEMPACIFIC 38184

Base Information

• Chemical Name: CHEMPACIFIC 38184
• CAS No.: 1620-71-9
• Molecular Formula: C7H6F3N
• Molecular Weight: 161.12
• Mol file: 1620-71-9.mol

Synonyms:CHEMPACIFIC 38184;5-Methyl-2-trifluoromethyl-pyridine;

Chemical Property of CHEMPACIFIC 38184

Chemical Property:

• Vapor Pressure: 5.66mmHg at 25°C
• Refractive Index: 1.429
• Boiling Point: 147.2 °C at 760 mmHg
• PKA: 0.84±0.22(Predicted)
• Flash Point: 42.8 °C
• PSA: 12.89000
• Density: 1.216 g/cm³
• LogP: 2.40880
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

5-Methyl-2-(trifluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Methyl-2-(trifluoromethyl)pyridine is a pyridine based building block used in chemical synthesis.

Technology Process of CHEMPACIFIC 38184

There total 2 articles about CHEMPACIFIC 38184 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Bromo-5-methylpyridine (3510-66-5) + trifluoromethylcopper(I) (77152-08-0) → 5-methyl-2-(trifluoromethyl)pyridine (1620-71-9)

Guidance literature:

With triethylamine tris(hydrogen fluoride); In N,N-dimethyl-formamide; at 23 - 50 ℃; for 33h; Glovebox; Sealed tube;

DOI:10.1021/jo401423h

Reference yield:

→ 5-methyl-2-(trifluoromethyl)pyridine (1620-71-9)

Guidance literature:

Isopren, Trifluoracetonitril (418.5grad, 30 min) (neben dem 4-Methyl-Isomeren);

Reference yield:

5-methyl-2-(trifluoromethyl)pyridine (1620-71-9) → 2-(2-ethylsulfanylphenyl)-6-(trifluoromethyl)pyrazolo[43-c]pyridine

Guidance literature:

Multi-step reaction with 6 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 48 h / 20 °C

2.1: nitric acid; sulfuric acid / 2 h / 0 - 100 °C

3.1: phosphorus trichloride / 0.33 h / 100 °C

4.1: N,N-dimethyl-formamide dimethyl acetal / N,N-dimethyl-formamide / 2 h / 120 °C

4.2: 16 h / 20 °C

5.1: toluene / 0.67 h / 70 °C / Microwave irradiation

6.1: triphenylphosphine / toluene / 0.5 h / Reflux

With sulfuric acid; nitric acid; N,N-dimethyl-formamide dimethyl acetal; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; phosphorus trichloride; In dichloromethane; N,N-dimethyl-formamide; toluene;

upstream raw materials:

2-Bromo-5-methylpyridine

trifluoromethylcopper(I)

Refernces