Vatanidipine, (S)-

Base Information

Chemical Name:Vatanidipine, (S)-
CAS No.:134028-04-9
Molecular Formula:C₄₁H₄₂N₄O₆
Molecular Weight:686.808
Hs Code.:
UNII:NFC42BIS8D

Synonyms:Vatanidipine, (S)-;NFC42BIS8D;UNII-NFC42BIS8D;134028-04-9;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(4-(4-(diphenylmethyl)-1-piperazinyl)phenyl)ethyl methyl ester, (S)-;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(2-(4-(4-(diphenylmethyl)-1-piperazinyl)phenyl)ethyl) 5-methyl ester, (4S)-

Suppliers and Price of Vatanidipine, (S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Vatanidipine, (S)-

Chemical Property:

XLogP3:7.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:12
Exact Mass:686.31043507
Heavy Atom Count:51
Complexity:1250

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C(C(=C(N1)C)C(=O)OCCC2=CC=C(C=C2)N3CCN(CC3)C(C4=CC=CC=C4)C5=CC=CC=C5)C6=CC(=CC=C6)[N+](=O)[O-])C(=O)OC
Isomeric SMILES:CC1=C([C@@H](C(=C(N1)C)C(=O)OCCC2=CC=C(C=C2)N3CCN(CC3)C(C4=CC=CC=C4)C5=CC=CC=C5)C6=CC(=CC=C6)[N+](=O)[O-])C(=O)OC

Technology Process of Vatanidipine, (S)-

There total 4 articles about Vatanidipine, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76093-33-9
(R)-5-(methoxycarbonyl)-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid

: 134028-04-9,116308-55-5,134054-36-7
(4S)-(+)-2-<4-(4-Benzhydryl-1-piperazinyl)phenyl>ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / CH₂Cl₂; dimethylformamide / 2.5 h / 5 - 9 °C

2: CH₂Cl₂; dimethylformamide / 16 h / 5 °C

With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.108

Reference yield:

: 76093-34-0
(+)-(S)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)pyridine-3-carboxylic acid

: 134028-04-9,116308-55-5,134054-36-7
(4S)-(+)-2-<4-(4-Benzhydryl-1-piperazinyl)phenyl>ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / CH₂Cl₂; dimethylformamide / 2.5 h / 5 - 9 °C

2: CH₂Cl₂; dimethylformamide / 16 h / 5 °C

With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.108