N-benzyloxycarbonyl-O--D-serine p-bromophenacyl ester

Base Information

• Chemical Name: N-benzyloxycarbonyl-O--D-serine p-bromophenacyl ester
• CAS No.: 82667-04-7
• Molecular Formula: C₆₃H₈₅BrN₁₀O₂₀S₂
• Molecular Weight: 1446.46
• Mol file: 82667-04-7.mol

Synonyms:

Chemical Property of N-benzyloxycarbonyl-O--D-serine p-bromophenacyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-benzyloxycarbonyl-O--D-serine p-bromophenacyl ester

There total 1 articles about N-benzyloxycarbonyl-O--D-serine p-bromophenacyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzyloxycarbonyl-O-(N-t-butyloxycarbonyl-L-alanyl-S-acetamidomethyl-L-cysteinyl-L-valyl)-D-serine (82662-00-8) + N-benzyloxycarbonyl-O-(L-alanyl-S-acetamidomethyl-L-cysteinyl-L-valyl)-D-serine p-bromophenacyl ester trifluoroacetate → N-benzyloxycarbonyl-O--D-serine p-bromophenacyl ester (82667-04-7)

Guidance literature:

With 4-methyl-morpholine; isobutyl chloroformate; Yield given. Multistep reaction; 1.) THF, -20 deg C, 10 min, 2.) THF, -20 deg C, 15 min, room temperature, 1 h;

DOI:10.1016/0040-4020(82)85045-X

Reference yield: 93.0%

N-benzyloxycarbonyl-O--D-serine p-bromophenacyl ester (82667-04-7) → (Z)-D-Ser{(Z)-D-Ser[Boc-L-Ala-L-Cys(Acm)-L-Val]-L-Ala-L-Cys(Acm)-L-Val}-OH (713122-06-6)

Guidance literature:

With acetic acid; zinc; 1.) 0 deg C, 2 h, 2.) room temperature, 3 h;

DOI:10.1016/0040-4020(82)85045-X

upstream raw materials:

N-benzyloxycarbonyl-O-(N-t-butyloxycarbonyl-L-alanyl-S-acetamidomethyl-L-cysteinyl-L-valyl)-D-serine

Downstream raw materials:

(Z)-D-Ser{(Z)-D-Ser[Boc-L-Ala-L-Cys(Acm)-L-Val]-L-Ala-L-Cys(Acm)-L-Val}-OH