2-((1H-tetrazol-5-yl)methyl)isoindoline-1,3-dione

Base Information

• Chemical Name: 2-((1H-tetrazol-5-yl)methyl)isoindoline-1,3-dione
• CAS No.: 114841-44-0
• Molecular Formula: C₁₀H₇N₅O₂
• Molecular Weight: 229.198
• Mol file: 114841-44-0.mol

Synonyms:

Chemical Property of 2-((1H-tetrazol-5-yl)methyl)isoindoline-1,3-dione

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

2-(1H-Tetrazol-5-ylmethyl)-1H-isoindole-1,3(2H)-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-((1H-tetrazol-5-yl)methyl)isoindoline-1,3-dione

There total 4 articles about 2-((1H-tetrazol-5-yl)methyl)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-(cyanomethyl)phthalimide (3842-20-4) → 2-((1H-tetrazol-5-yl)methyl)isoindoline-1,3-dione (114841-44-0)

Guidance literature:

With sodium azide; In water; isopropyl alcohol; for 4h; Reflux;

DOI:10.1002/jhet.2591

Reference yield: 90.4%

N-(cyanomethyl)phthalimide (3842-20-4) → 2-[(2H-tetrazol-5-yl)methyl]isoindoline-1,3-dione (114841-44-0)

Guidance literature:

With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 120 ℃; for 3h;

DOI:10.1002/jhet.1119

Reference yield:

phthalimide (136918-14-4,85-41-6) → 2-((1H-tetrazol-5-yl)methyl)isoindoline-1,3-dione (114841-44-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; potassium carbonate; tetra-(n-butyl)ammonium iodide / acetonitrile / Reflux

2: sodium azide / water; isopropyl alcohol / 4 h / Reflux

With sodium azide; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; In water; isopropyl alcohol; acetonitrile;

DOI:10.1002/jhet.2591

upstream raw materials:

N-(cyanomethyl)phthalimide

phthalimide

Downstream raw materials:

(1H-tetrazol-5-yl)methanamine