Synonyms:2,3-Dimethoxy-9,10-seco-12β,13β-strychnidin-10-saeure;4-NITROPHTHALIC ACID ANHYDRIDE;4-NITROPHTHALIC ANHYDRIDE;
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There total 1 articles about 4-Nitrophthalic anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
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The research focuses on the efficient synthesis of 7-amino-3-hydroxyindan-1-one, a three-dimensional, three-point scaffold with potential applications in constructing focused compound libraries for biological interactions. The synthesis is achieved through a three-step process: first, reacting 4-nitrophthalic anhydride with ethyl acetoacetate, acetic anhydride, and triethylamine in methylene chloride to produce compound 10; second, hydrolyzing and decarboxylating compound 10 with trifluoroacetic acid in acetonitrile to yield 4-nitroindan-1,3-dione (11); and third, reducing compound 11 using catalytic hydrogenation with 10% Pd/C in methanol to obtain the final product, 7-amino-3-hydroxyindan-1-one (7). The structure of compound 7 was confirmed using heteronuclear multiple bond correlation (HMBC) spectral studies. The article also details the preparation of N-substituted derivatives of compound 7 and provides their physical constants, spectral data, and yields. Analytical techniques used include NMR spectroscopy, LC/MS, and melting point determination, ensuring the purity and structure of the synthesized compounds.
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