(E)-1-(2-Methoxymethyloxy-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine fumarate

Base Information

Chemical Name:(E)-1-(2-Methoxymethyloxy-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine fumarate
CAS No.:139305-61-6
Molecular Formula:3C₄H₄O₄*2C₂₉H₃₂N₂O₃
Molecular Weight:1261.39
Hs Code.:

(E)-1-(2-Methoxymethyloxy-6,11-dihydrodibenz<b,e>oxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine fumarate

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Chemical Property of (E)-1-(2-Methoxymethyloxy-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine fumarate

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Technology Process of (E)-1-(2-Methoxymethyloxy-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine fumarate

There total 10 articles about (E)-1-(2-Methoxymethyloxy-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine fumarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 87-41-2
2-benzofuran-1(3H)-one

: 139305-61-6
(E)-1-(2-Methoxymethyloxy-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine fumarate

Guidance literature:: Multi-step reaction with 9 steps

1: 1 h / 200 °C

2: 89 percent / (CF₃CO)2O, BF₃*Et₂O / CH₂Cl₂ / 1 h / Ambient temperature

3: 71 percent / pyridine*HCl / 2 h / 180 °C

4: 90 percent / imidazole / dimethylformamide / 1 h / Ambient temperature

5: NaBH₄ / methanol / 0.33 h / 0 °C

6: SOCl₂ / 0.17 h / Ambient temperature

7: 87 percent / CH₂Cl₂ / 1 h / Ambient temperature

8: 69 percent / Bu₄NF / tetrahydrofuran / 0.5 h / Ambient temperature

9: 1) NaH / 1) DMF, 0 deg C, 5 min 2) 1 h

With 1H-imidazole; sodium tetrahydroborate; thionyl chloride; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; pyridine hydrochloride; sodium hydride; trifluoroacetic anhydride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2564

Reference yield:

: 23560-67-0
2-methoxy-6,11-dihydrodibenz[b,e]oxepin-11-one

: 139305-61-6
(E)-1-(2-Methoxymethyloxy-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine fumarate

Guidance literature:: Multi-step reaction with 7 steps

1: 71 percent / pyridine*HCl / 2 h / 180 °C

2: 90 percent / imidazole / dimethylformamide / 1 h / Ambient temperature

3: NaBH₄ / methanol / 0.33 h / 0 °C

4: SOCl₂ / 0.17 h / Ambient temperature

5: 87 percent / CH₂Cl₂ / 1 h / Ambient temperature

6: 69 percent / Bu₄NF / tetrahydrofuran / 0.5 h / Ambient temperature

7: 1) NaH / 1) DMF, 0 deg C, 5 min 2) 1 h

With 1H-imidazole; sodium tetrahydroborate; thionyl chloride; tetrabutyl ammonium fluoride; pyridine hydrochloride; sodium hydride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2564

Reference yield:

: 23560-68-1
2-<(4-Methoxyphenyl)oxymethyl>benzoic acid

: 139305-61-6
(E)-1-(2-Methoxymethyloxy-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine fumarate

Guidance literature:: Multi-step reaction with 8 steps

1: 89 percent / (CF₃CO)2O, BF₃*Et₂O / CH₂Cl₂ / 1 h / Ambient temperature

2: 71 percent / pyridine*HCl / 2 h / 180 °C

3: 90 percent / imidazole / dimethylformamide / 1 h / Ambient temperature

4: NaBH₄ / methanol / 0.33 h / 0 °C

5: SOCl₂ / 0.17 h / Ambient temperature

6: 87 percent / CH₂Cl₂ / 1 h / Ambient temperature

7: 69 percent / Bu₄NF / tetrahydrofuran / 0.5 h / Ambient temperature

8: 1) NaH / 1) DMF, 0 deg C, 5 min 2) 1 h

With 1H-imidazole; sodium tetrahydroborate; thionyl chloride; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; pyridine hydrochloride; sodium hydride; trifluoroacetic anhydride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2564