(1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:180272-45-1
Molecular Formula:C15H15N
Molecular Weight:209.291
Hs Code.:
European Community (EC) Number:813-246-6
DSSTox Substance ID:DTXSID40362553
Nikkaji Number:J825.517B
Wikidata:Q72498848
Mol file:180272-45-1.mol

Synonyms:180272-45-1;(1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline;(R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline;(R)-1-Phenyl-1,2,3,4-tetrahydro-isoquinoline;Isoquinoline, 1,2,3,4-tetrahydro-1-phenyl-, (1R)-;SCHEMBL1668148;DTXSID40362553;CS-M0032;MFCD11858641;AKOS016843427;AC-4740;DS-16690;P2215;1beta-Phenyl-1,2,3,4-tetrahydroisoquinoline;EN300-224816;Z1509142487

Suppliers and Price of (1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline
10 g
$ 1455.00

TCI Chemical
(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline
200MG
$ 176.00

Medical Isotopes, Inc.
(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline
25 g
$ 625.00

J&W Pharmlab
(R)-1-Phenyl-1,2,3,4-tetrahydro-isoquinoline 97%
100mg
$ 260.00

J&W Pharmlab
(R)-1-Phenyl-1,2,3,4-tetrahydro-isoquinoline 97%
50mg
$ 180.00

J&W Pharmlab
(R)-1-Phenyl-1,2,3,4-tetrahydro-isoquinoline 97%
1g
$ 1380.00

J&W Pharmlab
(R)-1-Phenyl-1,2,3,4-tetrahydro-isoquinoline 97%
5g
$ 4880.00

J&W Pharmlab
(R)-1-Phenyl-1,2,3,4-tetrahydro-isoquinoline 97%
500mg
$ 740.00

J&W Pharmlab
(R)-1-Phenyl-1,2,3,4-tetrahydro-isoquinoline 97%
250mg
$ 420.00

Crysdot
(1R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline 98%
5g
$ 446.00

Total 55 raw suppliers

Chemical Property of (1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Melting Point:78-79℃
Boiling Point:338.4 °C at 760 mmHg
Flash Point:166.9 °C
PSA：12.03000
Density:1.065 g/cm³
LogP:3.25050
Storage Temp.:2-8°C
Solubility.:Chloroform (Slightly), Dichloromethane (Sparingly), DMSO (Slightly), Methanol (Slightly)
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:209.120449483
Heavy Atom Count:16
Complexity:220

Purity/Quality:

99% ^*data from raw suppliers

(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNC(C2=CC=CC=C21)C3=CC=CC=C3
Isomeric SMILES:C1CN[C@@H](C2=CC=CC=C21)C3=CC=CC=C3
Uses (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is the counterpart to (S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline, the latter enantiomer being a key intermediate in the preparation of Solifenacin (S676700), an antimuscarinic agent. Since (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is produced as a by-product, it has been suggested that it should be recycled in order to obtain the S enantiomer on a larger scale. (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is also used as a reagent to prepare quinuclidin-3-yl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives, compounds that act as muscarinic receptor antagonists.

Technology Process of (1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

There total 51 articles about (1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 220936-57-2
(R)-(+)-2-(4-methylphenylsulfonyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

: 180272-45-1
(R)-(-)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With samarium diiodide; water; triethylamine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1021/ol301281s

Reference yield: 93.0%

: 22990-19-8
1-phenyl-1,2,3,4-tetrahydroisoquinoline

: 180272-45-1
(R)-(-)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: 1-phenyl-1,2,3,4-tetrahydroisoquinoline; With N-Bromosuccinimide; bis(1,5-cyclooctadiene)diiridium(I) dichloride; sodium carbonate; (+)-(R)-[2,3,2',3'-tetrahydro-5,5'-bi(1,4-benzodioxin)-6,6'-diyl]bis(diphenylphosphane); In 1,2-dichloro-ethane; at 20 ℃; for 0.166667h;

With hydrogen; In 1,2-dichloro-ethane; at 30 ℃; for 24h; under 25858.1 Torr; enantioselective reaction;
DOI:10.1021/jacs.5b06659

Reference yield: 82.0%

: 321670-05-7
(1R)-N-(8-menthyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

: 180272-45-1
(R)-(-)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: (1R)-N-(8-menthyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline; With 3 A molecular sieve; sodium acetate; pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 48h;

With potassium hydroxide; In tetrahydrofuran; Further stages.;
DOI:10.1021/jo001397s