(+)(S)-methylethylacetic acid amide

Base Information

• Chemical Name: (+)(S)-methylethylacetic acid amide
• CAS No.: 13133-74-9
• Molecular Formula: C₅H₁₁NO
• Molecular Weight: 101.148
• Mol file: 13133-74-9.mol

Synonyms:

Chemical Property of (+)(S)-methylethylacetic acid amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (+)(S)-methylethylacetic acid amide

There total 2 articles about (+)(S)-methylethylacetic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-Methylbutyric acid (1730-91-2) → (+)(S)-methylethylacetic acid amide (13133-74-9) + (R)-2-methylbutanamide (389122-94-5)

Guidance literature:

With oxalyl dichloride; ammonia; N,N-dimethyl-formamide; In dichloromethane; at 0 - 23 ℃; Title compound not separated from byproducts.;

DOI:10.1021/ja066405m

Reference yield:

2-methylbutanenitrile (18936-17-9) → (+)(S)-methylethylacetic acid amide (13133-74-9) + (R)-2-methylbutanamide (389122-94-5)

Guidance literature:

With recombinant Sinorhizobium meliloti 1021 nitrile hydratase; water; at 21 ℃; pH=8; enantioselective reaction; Tris-HCl buffer;

DOI:10.1039/c0ob01067g

upstream raw materials:

(S)-2-Methylbutyric acid

2-methylbutanenitrile