(1R,2S)-2-<(8-isobutyl-6-phenyl-1,2,4-triazolo<4,3-a>pyrazin-3-yl)acetamido>-1,3-dicyclohexyl-1-hydroxypropane

Base Information

• Chemical Name: (1R,2S)-2-<(8-isobutyl-6-phenyl-1,2,4-triazolo<4,3-a>pyrazin-3-yl)acetamido>-1,3-dicyclohexyl-1-hydroxypropane
• CAS No.: 128972-35-0
• Molecular Formula: C₃₂H₄₅N₅O₂
• Molecular Weight: 531.742
• Mol file: 128972-35-0.mol

Synonyms:

Chemical Property of (1R,2S)-2-<(8-isobutyl-6-phenyl-1,2,4-triazolo<4,3-a>pyrazin-3-yl)acetamido>-1,3-dicyclohexyl-1-hydroxypropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S)-2-<(8-isobutyl-6-phenyl-1,2,4-triazolo<4,3-a>pyrazin-3-yl)acetamido>-1,3-dicyclohexyl-1-hydroxypropane

There total 10 articles about (1R,2S)-2-<(8-isobutyl-6-phenyl-1,2,4-triazolo<4,3-a>pyrazin-3-yl)acetamido>-1,3-dicyclohexyl-1-hydroxypropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromocyclohexane (108-85-0) → (1R,2S)-2-<(8-isobutyl-6-phenyl-1,2,4-triazolo<4,3-a>pyrazin-3-yl)acetamido>-1,3-dicyclohexyl-1-hydroxypropane (128972-35-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) Mg / 1.) ether, 2.) from -20 deg C to RT, 18 h

2: HCl / dioxane

3: 1-hydroxybenzotriazole (HOBT), triethylamine, 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 18 h / Ambient temperature

With hydrogenchloride; benzotriazol-1-ol; magnesium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1021/jm00171a005

Reference yield:

2-aminoacetophenone hydrochloride (5468-37-1) → (1R,2S)-2-<(8-isobutyl-6-phenyl-1,2,4-triazolo<4,3-a>pyrazin-3-yl)acetamido>-1,3-dicyclohexyl-1-hydroxypropane (128972-35-0)

Guidance literature:

Multi-step reaction with 8 steps

1: 1.) 1,3-dicyclohexylcarbodiimide (DCC), 2.) 1-hydroxybenzotriazole hydrate (HOBT) / CH₂Cl₂

2: ammonium acetate / ethanol / 3.5 h / Heating

3: COCl₂ / toluene; tetrahydrofuran / 4 h / Heating

4: H₂N-NH₂*H₂O / dimethylsulfoxide / 2 h / Heating

5: ethyl acetate / 1 h / 0 °C

6: p-toluenesulfonic acid monohydrate (PTSA) / toluene / 2.5 h / Heating

7: 2 M aq. NaOH / ethanol / 1 h

8: 1-hydroxybenzotriazole (HOBT), triethylamine, 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 18 h / Ambient temperature

With ammonium acetate; sodium hydroxide; benzotriazol-1-ol; toluene-4-sulfonic acid; hydrazine hydrate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm00171a005

Reference yield:

(S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal (98105-42-1) → (1R,2S)-2-<(8-isobutyl-6-phenyl-1,2,4-triazolo<4,3-a>pyrazin-3-yl)acetamido>-1,3-dicyclohexyl-1-hydroxypropane (128972-35-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) Mg / 1.) ether, 2.) from -20 deg C to RT, 18 h

2: HCl / dioxane

3: 1-hydroxybenzotriazole (HOBT), triethylamine, 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 18 h / Ambient temperature

With hydrogenchloride; benzotriazol-1-ol; magnesium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1021/jm00171a005

upstream raw materials:

1-bromocyclohexane

2-aminoacetophenone hydrochloride

(S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal

(5-Phenyl-3-propyl-pyrazin-2-yl)-hydrazine