VTX-27

Base Information

Chemical Name:VTX-27
CAS No.:1321924-70-2
Molecular Formula:C₂₀H₂₄ClFN₆O
Molecular Weight:418.902
Hs Code.:
Mol file:1321924-70-2.mol

Synonyms:

Suppliers and Price of VTX-27

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
VTX-27
1mg
$ 501.00

DC Chemicals
VTX-27 >98%
250 mg
$ 1600.00

DC Chemicals
VTX-27 >98%
100 mg
$ 950.00

ChemScene
VTX-27 99.64%
2mg
$ 260.00

ChemScene
VTX-27 99.64%
5mg
$ 520.00

ChemScene
VTX-27 99.64%
10mg
$ 850.00

ChemScene
VTX-27 99.64%
100mg
$ 3950.00

ChemScene
VTX-27 99.64%
50mg
$ 2750.00

ChemScene
VTX-27 99.64%
25mg
$ 1750.00

Biorbyt Ltd
VTX-27 >98%
1 g
$ 8916.50

Total 11 raw suppliers

Chemical Property of VTX-27

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

VTX-27 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of VTX-27

There total 15 articles about VTX-27 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1321925-15-8
3-(4-(tert-butyldimethylsilyl)-5-chloro-3-fluoro-6-((S)-3-((R)-3-methyl-2-(trimethylsilyloxy)butan-2-yl)piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridine

: 1321924-70-2
(R)-2-((S)-4-(3-chloro-5-fluoro-6-(1H-pyrazolo[3,4-b]pyridine-3-yl)pyridine-2-yl)piperazin-2-yl)-3-methylbutan-2-ol

Guidance literature:: 3-(4-(tert-butyldimethylsilyl)-5-chloro-3-fluoro-6-((S)-3-((R)-3-methyl-2-(trimethylsilyloxy)butan-2-yl)piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridine; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 - 27.7 ℃;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield: 70.0%

: 1321503-96-1
(R)-3-methyl-2-((S)-piperazin-2-yl)butan-2-ol

: 1321925-30-7
C₁₁H₅ClF₂N₄

: 1321924-70-2
(R)-2-((S)-4-(3-chloro-5-fluoro-6-(1H-pyrazolo[3,4-b]pyridine-3-yl)pyridine-2-yl)piperazin-2-yl)-3-methylbutan-2-ol

Guidance literature:: (R)-3-methyl-2-((S)-piperazin-2-yl)butan-2-ol; C₁₁H₅ClF₂N₄; In 1-methyl-pyrrolidin-2-one; at 90 ℃; for 10h;

With sodium hydroxide; In 1-methyl-pyrrolidin-2-one; water; at 20 ℃; for 0.5h;

Reference yield:

: 563-80-4
3-methyl-butan-2-one

: 1321924-70-2
(R)-2-((S)-4-(3-chloro-5-fluoro-6-(1H-pyrazolo[3,4-b]pyridine-3-yl)pyridine-2-yl)piperazin-2-yl)-3-methylbutan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / hexane; tetrahydrofuran / -78 - 0 °C / Inert atmosphere

1.2: -78 - -60 °C

2.1: cellulose-2 column (Phenomenex) / acetonitrile / 35 °C / Resolution of racemate

3.1: hydrogen / platinum(IV) oxide / methanol / 3102.97 Torr / Inert atmosphere

4.1: 1-methyl-pyrrolidin-2-one / 10 h / 90 °C

4.2: 0.5 h / 20 °C

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; hydrogen; platinum(IV) oxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; hexane; acetonitrile;