Fluvoxamine

Base Information

Chemical Name:Fluvoxamine
CAS No.:54739-18-3
Molecular Formula:C₁₅H₂₁F₃N₂O₂
Molecular Weight:318.339
Hs Code.:2928000090
European Community (EC) Number:611-193-1
UNII:O4L1XPO44W
DSSTox Substance ID:DTXSID2044002
Nikkaji Number:J1.245.131H,J453.182E,J11.936I
Wikipedia:Fluvoxamine
Wikidata:Q27259474
NCI Thesaurus Code:C61769
RXCUI:42355
Pharos Ligand ID:CH1FF2M6Z9W4
Metabolomics Workbench ID:42584
ChEMBL ID:CHEMBL814
Mol file:54739-18-3.mol

Synonyms:Desiflu;DU 23000;DU-23000;DU23000;Dumirox;Faverin;Fevarin;Floxyfral;Fluvoxadura;Fluvoxamin AL;Fluvoxamin beta;Fluvoxamin neuraxpharm;Fluvoxamin ratiopharm;Fluvoxamin Stada;Fluvoxamin-neuraxpharm;Fluvoxamin-ratiopharm;Fluvoxamina Geminis;Fluvoxamine;Fluvoxamine Maleate;Fluvoxamine Maleate, (E)-Isomer;Fluvoxamine, (Z)-Isomer;Geminis, Fluvoxamina;Luvox;Novo Fluvoxamine;Novo-Fluvoxamine;Nu Fluvoxamine;Nu-Fluvoxamine;PMS Fluvoxamine;PMS-Fluvoxamine;ratio Fluvoxamine;ratio-Fluvoxamine

Suppliers and Price of Fluvoxamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Fluvoxamine
100mg
$ 470.00

TRC
Fluvoxamine
250mg
$ 1070.00

Medical Isotopes, Inc.
Fluvoxamine
25 mg
$ 610.00

Medical Isotopes, Inc.
Fluvoxamine
250 mg
$ 1380.00

Matrix Scientific
(E)-5-Methoxy-1-(4-(trifluoromethyl)phenyl)-pentan-1-one O-(2-aminoethyl) oxime 95+%
5g
$ 1857.00

Matrix Scientific
(E)-5-Methoxy-1-(4-(trifluoromethyl)phenyl)-pentan-1-one O-(2-aminoethyl) oxime 95+%
1g
$ 688.00

Matrix Scientific
(E)-5-Methoxy-1-(4-(trifluoromethyl)phenyl)-pentan-1-one O-(2-aminoethyl) oxime 95+%
500mg
$ 447.00

CSNpharm
Fluvoxamine
50mg
$ 89.00

Crysdot
Fluvoxamine 98+%
100mg
$ 84.00

Crysdot
Fluvoxamine 98+%
50mg
$ 67.00

Total 88 raw suppliers

Chemical Property of Fluvoxamine

Chemical Property:

Vapor Pressure:1.1E-05mmHg at 25°C
Melting Point:120-122.5°C
Boiling Point:370.6°C at 760 mmHg
PKA:pKa 8.7 (Uncertain)
Flash Point:177.9°C
PSA：56.84000
Density:1.16±0.1 g/cm3(Predicted)
LogP:3.90180
Storage Temp.:-20°C Freezer, Under Inert Atmosphere
Solubility.:Chloroform (Sparingly), DMSO (Slightly), Methanol (Slightly)
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:9
Exact Mass:318.15551240
Heavy Atom Count:22
Complexity:327

Purity/Quality:

99%, ^*data from raw suppliers

Fluvoxamine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Drug Classes:Antidepressant Agents
Canonical SMILES:COCCCCC(=NOCCN)C1=CC=C(C=C1)C(F)(F)F
Isomeric SMILES:COCCCC/C(=N\OCCN)/C1=CC=C(C=C1)C(F)(F)F
Recent ClinicalTrials:Vortioxetine in the Elderly vs. Selective Serotonin Reuptake Inhibitors (SSRIs): a Pragmatic Assessment
Recent EU Clinical Trials:ASSESSING TOLERABILITY AND EFFICACY OF VORTIOXETINE VERSUS SSRIs IN ELDERLY PATIENTS WITH DEPRESSION: A PRAGMATIC, MULTICENTER, OPEN-LABEL, PARALLEL-GROUP, SUPERIORITY, RANDOMIZED TRIAL
Recent NIPH Clinical Trials:Evaluation of drug interactions of cytochrome P450 by single-substrate administrations and the cocktail method
Uses A selective serotonin reuptake inhibitor (SSRI) used as an anti-depressant. A selective serotonin reuptake inhibitor (SSRI) used as an anti-depressant
Therapeutic Function Antidepressant
Clinical Use Fluvoxamine is approved for use in obsessive-compulsive disorders.
Drug interactions In vitro studies have shown fluvoxamine to be a potent inhibitor of CYP1A2, to inhibit CYP3A4 and CYP2C19, and to weakly inhibit CYP2D6. The bioavailability of fluvoxamine is significantly decreased in smokers compared with nonsmokers, possibly because of induction of CYP1A metabolism of fluvoxamine. Therefore, interactions with drugs that inhibit CYP1A2 also should be considered (e.g., theophylline and caffeine).

Technology Process of Fluvoxamine

There total 5 articles about Fluvoxamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: (E)-N-{5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene}hydroxylamine

: 870-24-6
2-chloroethanamine hydrochloride

: 54739-18-3,61718-81-8,89035-92-7
fluvoxamine

Guidance literature:: With potassium hydroxide; In N,N-dimethyl-formamide; at 10 - 20 ℃;
DOI:10.1016/j.ejmech.2021.113533

Reference yield:

: 61718-80-7
5-methoxy-1-[4-(trifluoromethyl)phenyl]pentan-1-one

: 54739-18-3,61718-81-8,89035-92-7
fluvoxamine

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol / 3 h / 20 °C

2: potassium hydroxide / N,N-dimethyl-formamide / 10 - 20 °C

With hydroxylamine hydrochloride; sodium acetate; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2021.113533

Reference yield:

: 455-18-5
4-CF₃C₆H₄CN

: 54739-18-3,61718-81-8,89035-92-7
fluvoxamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium; ethylene dibromide / diethyl ether / Inert atmosphere

1.2: 8 h / Inert atmosphere; Reflux

2.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 3 h / 20 °C

3.1: potassium hydroxide / N,N-dimethyl-formamide / 10 - 20 °C

With hydroxylamine hydrochloride; sodium acetate; magnesium; ethylene dibromide; potassium hydroxide; In diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2021.113533