5-Bromo-2-(4-morpholinyl)-3-pyridinecarboxylic acid

Base Information

• Chemical Name: 5-Bromo-2-(4-morpholinyl)-3-pyridinecarboxylic acid
• CAS No.: 1017783-03-7
• Molecular Formula: C10H11BrN2O3
• Molecular Weight: 287.10994
• Hs Code.: 2934999090
• Mol file: 1017783-03-7.mol

Synonyms:5-Bromo-2-(4-morpholinyl)-3-pyridinecarboxylic acid

Chemical Property of 5-Bromo-2-(4-morpholinyl)-3-pyridinecarboxylic acid

Chemical Property:

• Melting Point: 168～170℃
• PSA: 62.66000
• Density: 1.643
• LogP: 1.44390
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-2-morpholinonicotinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-2-(4-morpholinyl)-3-pyridinecarboxylic acid

There total 3 articles about 5-Bromo-2-(4-morpholinyl)-3-pyridinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

methyl 5-bromo-2-morpholinonicotinate (1017782-99-8) → 5-bromo-2-morpholinonicotinic acid (1017783-03-7)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃;

Reference yield: 45.8%

morpholine (110-91-8,99108-56-2) + 5-bromo-2-fluoro-pyridine-3-carboxylic acid (29241-66-5) → 5-bromo-2-morpholinonicotinic acid (1017783-03-7)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 2h;

Reference yield:

methyl 2-chloro-5-bromonicotinate (78686-79-0) → 5-bromo-2-morpholinonicotinic acid (1017783-03-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1 h / 120 °C

2: lithium hydroxide; water / tetrahydrofuran / 20 °C

With water; lithium hydroxide; In tetrahydrofuran;

upstream raw materials:

morpholine

5-bromo-2-fluoro-pyridine-3-carboxylic acid

methyl 2-chloro-5-bromonicotinate

methyl 5-bromo-2-morpholinonicotinate

Downstream raw materials:

methyl 5-bromo-2-morpholinonicotinate

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