PKR Inhibitor

Base Information

• Chemical Name: PKR Inhibitor
• CAS No.: 608512-97-6
• Molecular Formula: C13H8N4OS
• Molecular Weight: 268.29
• European Community (EC) Number: 685-966-7
• UNII: C9Q75QZK84
• Wikipedia: C16_(drug)
• Wikidata: Q5007568
• Pharos Ligand ID: SV93WC5FRAJ3
• ChEMBL ID: CHEMBL235641
• Mol file: 608512-97-6.mol

Synonyms:PKR Inhibitor;608512-97-6;C16 (PKR inhibitor);PKR-IN-C16;AC1O5VPR;Imidazolo-oxindole PKR inhibitor C16;ASN 11124542;1159885-47-8;C16;GW-506033X;C9Q75QZK84;CHEMBL235641;(Z)-8-((1H-Imidazol-4-yl)methylene)-6H-thiazolo[5,4-e]indol-7(8H)-one;8-(1H-IMIDAZOL-4-YLMETHYLENE)-6,8-DIHYDRO-THIAZOLO[5,4-E]INDOL-7-ONE;C-16;8-((1H-Imidazol-4-yl)methylene)-6,8-dihydro-7H-thiazolo[5,4-e]indol-7-one;(8Z)-8-(1H-imidazol-5-ylmethylidene)-6H-pyrrolo[2,3-g][1,3]benzothiazol-7-one;6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one;(8Z)-8-(1H-Imidazol-5-ylmethylidene)-6H,7H,8H-(1,3)thiazolo(5,4-E)indol-7-one;(Z)-8-((1H-Imidazol-4-yl)methylene)-6,8-dihydro-7H-thiazolo[5,4-e]indol-7-one;6,8-dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo(2,3-g)benzothiazol-7-one;7H-Pyrrolo(2,3-g)benzothiazol-7-one, 6,8-dihydro-8-(1H-imidazol-5-ylmethylene)-;7H-Pyrrolo(2,3-g)benzothiazol-7-one, 6,8-dihydro-8-(1H-imidazol-5-ylmethylene)-, (8Z)-;(8Z)-8-(1H-imidazol-5-ylmethylidene)-6H,7H,8H-[1,3]thiazolo[5,4-e]indol-7-one;D0C1DQ;UNII-C9Q75QZK84;GTPL6026;SCHEMBL9886520;HMS3229I15;BDBM50506912;HY-13977A;MFCD06735404;s9668;AKOS025147356;AKOS040742427;CCG-206776;NCGC00387501-01;AC-35803;ASN-11124542;WS-03077;PKR Inhibitor - CAS 608512-97-6;CS-0009102;E71342;Q5007568;Imidazolo-oxindole PKR inhibitor C16, >=98% (HPLC);7H-Pyrrolo[2,3-g]benzothiazol-7-one, 6,8-dihydro-8-(1H-imidazol-5-ylmethylene);(8Z)-8-[(1H-IMIDAZOL-5-YL)METHYLIDENE]-6H,7H,8H-[1,3]THIAZOLO[5,4-E]INDOL-7-ONE

Chemical Property of PKR Inhibitor

Chemical Property:

• Boiling Point: 674.6±55.0 °C(Predicted)
• PKA: 10.20±0.20(Predicted)
• PSA: 98.91000
• Density: 1.604±0.06 g/cm3(Predicted)
• LogP: 2.65010
• Storage Temp.: ?20°C
• Solubility.: DMSO: soluble12mg/mL
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 268.04188206
• Heavy Atom Count: 19
• Complexity: 427

Purity/Quality:

98%,99%, ^*data from raw suppliers

Imidazolo-oxindolePKRinhibitorC16(PKRInhibitor) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C3=C1NC(=O)C3=CC4=CN=CN4)SC=N2
• Isomeric SMILES: C1=CC2=C(C\3=C1NC(=O)/C3=C\C4=CN=CN4)SC=N2
• Description: The activity of double-stranded RNA-activated protein kinase (PKR) is altered by viral infection as well as by various neuropathologies. A primary phosphorylation target of PKR is eukaryotic initiation factor 2 subunit α (eIF2α), blocking translation and driving apoptosis. PKR Inhibitor is an oxindole/imidazole derivative that binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM. PKR Inhibitor protects human neuroblastoma cells against cell damage triggered by tunicamycin-mediated endoplasmic reticulum stress. It also prevents phosphorylation of Fas-associated protein with a death domain (FADD) in neuroblastoma cells, preventing FADD-dependent activation of caspases and apoptosis. Intraperitoneal administration of PKR inhibitor in rats reduces phosphorylation of PKR and eIF2α in the brain. Similar administration in mice enhances long-term memory storage, including contextual and auditory long-term fear memories.
• Uses: PKR Inhibitor is a drug which acts as a selective inhibitor of the enzyme double-stranded RNA-dependent protein kinase (PKR). It has been shown to effectively inhibit PKR function in vivo and has neuroprotective and nootropic effects in animal studies.

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