xav-939

Base Information

• Chemical Name: xav-939
• CAS No.: 284028-89-3
• Molecular Formula: C14H11F3N2OS
• Molecular Weight: 312.315
• Hs Code.: 29349990
• Mol file: 284028-89-3.mol

Synonyms:XAV 939;

Chemical Property of xav-939

Chemical Property:

• Boiling Point: 429.3 °C at 760 mmHg
• PKA: 0.23±0.20(Predicted)
• Flash Point: 213.4 °C
• PSA: 71.31000
• Density: 1.5 g/cm³
• LogP: 3.65730
• Storage Temp.: Store at RT
• Solubility.: DMSO: soluble5mg/mL, clear

Purity/Quality:

99%, ^*data from raw suppliers

XAV 939 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25-36
• Safety Statements: 26-45-26/45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Description: XAV-939 (284028-89-3) is a tankyrase inhibitor (IC50=11 and 4 nM for TNKS1 and 2 respectively).? Antagonizes wnt signaling via stimulation of β-catenin degradation and stabilization of actin.1? XAV-939 robustly induces cardiomyogenesis of stem cells.2? Cell permeable
• Uses: A tankyrase (TNKS) inhibitor that antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. It inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1. XAV939 has been used in the inhibition of tankyrase in neuroblastoma cell lines of diphtheria toxin-like ADP-ribosyltransferases (ARTD) in medulloblastoma cells of wnt signalling in human induced pluripotent stem cells (hiPSCs)

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