5,7-dichloroiMidazo[1,2-c]pyriMidine

Base Information

• Chemical Name: 5,7-dichloroiMidazo[1,2-c]pyriMidine
• CAS No.: 85989-61-3
• Molecular Formula: C6H3Cl2N3
• Molecular Weight: 188.01
• Hs Code.: 2933990090
• Mol file: 85989-61-3.mol

Synonyms:5,7-dichloroimidazo[1,2-f]pyrimidine;5,7-DICHLOROIMIDAZO[2,1-F]PYRIMIDINE;5,7-dichloro-imidazo<1,2-c>pyrimidine;

Chemical Property of 5,7-dichloroiMidazo[1,2-c]pyriMidine

Chemical Property:

• PKA: 1.91±0.30(Predicted)
• PSA: 30.19000
• Density: 1.69±0.1 g/cm3(Predicted)
• LogP: 2.03610
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

5,7-Dichloroimidazo[1,2-c]pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,7-dichloroiMidazo[1,2-c]pyriMidine

There total 3 articles about 5,7-dichloroiMidazo[1,2-c]pyriMidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

7-chloroimidazo[1,2-c]pyrimidin-5-ol (56817-09-5) → 5,7-dichloro-imidazo<1,2-c>pyrimidine (85989-61-3)

Guidance literature:

7-chloroimidazo[1,2-c]pyrimidin-5-ol; With trichlorophosphate; at 120 ℃; for 4h; Inert atmosphere;

With sodium hydrogencarbonate; In water; pH=7;

Reference yield:

7-chloro-5-(methylthio)imidazo[1,2-c]pyrimidine (872059-27-3) → 5,7-dichloro-imidazo<1,2-c>pyrimidine (85989-61-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / water; methanol / 2 h / Reflux

2: trichlorophosphate / 4 h / Reflux

With potassium hydroxide; trichlorophosphate; In methanol; water;

DOI:10.1021/ml500352s

Reference yield:

2,6-dichloro-4-(2,2-diethoxyethyl)amino-pyrimidine → 5,7-dichloro-imidazo<1,2-c>pyrimidine (85989-61-3)

Guidance literature:

With sulfuric acid; trichlorophosphate; Yield given. Multistep reaction; 1.) conc. H₂SO₄, 65 deg C, 2 h; 2.) POCl₃, 105 deg C, 48 h;

DOI:10.1016/S0031-9422(00)81474-0

upstream raw materials:

7-chloroimidazo[1,2-c]pyrimidin-5-ol

7-chloro-5-(methylthio)imidazo[1,2-c]pyrimidine