4-Amino-2,3-difluorobenzonitrile

Base Information

Chemical Name:4-Amino-2,3-difluorobenzonitrile
CAS No.:112279-71-7
Molecular Formula:C7H4F2N2
Molecular Weight:154.119
Hs Code.:2926909090
DSSTox Substance ID:DTXSID70562302
Wikidata:Q72435868
Mol file:112279-71-7.mol

Synonyms:4-Amino-2,3-difluorobenzonitrile;112279-71-7;C7H4F2N2;MFCD09030642;4-Amino-2,3-difluoro-benzonitrile;2,3-Difluoro-4-cyanoaniline;4-AMINO-2,3-DIFLOROBENZONITRILE;SCHEMBL9340535;DTXSID70562302;SITORLJYAUMNMW-UHFFFAOYSA-N;CL8199;AKOS015964285;DS-2077;PS-8895;SB76136;SY101437;4-Amino-2 pound not3-difluorobenzonitrile;CS-0134998;A894612;J-002741

Suppliers and Price of 4-Amino-2,3-difluorobenzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Amino-2,3-Difluorobenzonitrile
100mg
$ 60.00

SynQuest Laboratories
4-Amino-2,3-difluorobenzonitrile
1 g
$ 64.00

SynQuest Laboratories
4-Amino-2,3-difluorobenzonitrile
5 g
$ 256.00

Crysdot
4-Amino-2,3-difluorobenzonitrile 95+%
5g
$ 220.00

Chemenu
4-Amino-2,3-difluorobenzonitrile 95%
5g
$ 271.00

Apolloscientific
4-Amino-2,3-difluorobenzonitrile
5g
$ 160.00

Apolloscientific
4-Amino-2,3-difluorobenzonitrile
1g
$ 40.00

American Custom Chemicals Corporation
4-AMINO-2,3-DIFLUOROBENZONITRILE 95.00%
5MG
$ 500.52

Ambeed
4-Amino-2,3-difluorobenzonitrile 95+%
1g
$ 65.00

Ambeed
4-Amino-2,3-difluorobenzonitrile 95+%
250mg
$ 30.00

Total 36 raw suppliers

Chemical Property of 4-Amino-2,3-difluorobenzonitrile

Chemical Property:

Vapor Pressure:0.0076mmHg at 25°C
Melting Point:108-110 °C
Refractive Index:1.533
Boiling Point:269℃
PKA:-0.69±0.10(Predicted)
Flash Point:116℃
PSA：49.81000
Density:1.36
LogP:1.99988
Storage Temp.:2-8°C(protect from light)
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:154.03425446
Heavy Atom Count:11
Complexity:186

Purity/Quality:

97% ^*data from raw suppliers

4-Amino-2,3-Difluorobenzonitrile ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C(=C1C#N)F)F)N

Technology Process of 4-Amino-2,3-difluorobenzonitrile

There total 6 articles about 4-Amino-2,3-difluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: aqueous NaCN

: 4519-40-8
2,3-difluoroanilline

: copper(l) cyanide

: 112279-71-7
4-amino-2,3-difluoro-benzonitrile

Guidance literature:: With bromine; In water; acetic acid; N,N-dimethyl-formamide;

Reference yield: 55.0%

: CH₂

: aqueous NaCN

: 4519-40-8
2,3-difluoroanilline

: 7732-18-5
water

: copper(l) cyanide

: 112279-71-7
4-amino-2,3-difluoro-benzonitrile

Guidance literature:: With bromine; In acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 18355-79-8
N-(2,3-difluoro-phenyl)-acetamide

: 112279-71-7
4-amino-2,3-difluoro-benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: Br₂

2: Pd(dba)2 / dimethylformamide

3: aq. HCl / ethanol

With hydrogenchloride; bromine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.01.076