Lurasidone hydrochloride

Base Information

Chemical Name:Lurasidone hydrochloride
CAS No.:367514-88-3
Deprecated CAS:441351-20-8
Molecular Formula:C28H36N4O2S.HCl
Molecular Weight:529.146
Hs Code.:
European Community (EC) Number:682-423-6
UNII:O0P4I5851I
DSSTox Substance ID:DTXSID401027714
Wikidata:Q27882070
NCI Thesaurus Code:C77576
RXCUI:1040027
ChEMBL ID:CHEMBL1615372
Mol file:367514-88-3.mol

Synonyms:13496, SM;HCl, Lurasidone;Hydrochloride, Lurasidone;latuda;lurasidone;Lurasidone HCl;Lurasidone Hydrochloride;N-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinylmethyl)-1-cyclohexylmethyl)-2,3-bicyclo(2.2.1)heptanedicarboximide;SM 13,496;SM 13496;SM-13,496;SM-13496;SM13,496;SM13496

Suppliers and Price of Lurasidone hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
LurasidoneHydrochloride
5mg
$ 180.00

Sigma-Aldrich
Lurasidone hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
1 mL
$ 154.00

Sigma-Aldrich
Lurasidone hydrochloride solution
030-1ml
$ 149.00

Medical Isotopes, Inc.
LurasidoneHCl
5 mg
$ 590.00

DC Chemicals
LurasidoneHCl >98%
100 mg
$ 400.00

ChemScene
LurasidoneHydrochloride 99.87%
200mg
$ 288.00

ChemScene
LurasidoneHydrochloride 99.87%
100mg
$ 180.00

ChemScene
LurasidoneHydrochloride 99.87%
500mg
$ 600.00

ChemScene
LurasidoneHydrochloride 99.87%
50mg
$ 120.00

ChemScene
LurasidoneHydrochloride 99.87%
10mg
$ 72.00

Total 152 raw suppliers

Chemical Property of Lurasidone hydrochloride

Chemical Property:

Melting Point:198-205°C
Flash Point:9℃
PSA：84.99000
LogP:4.19660
Storage Temp.:Refrigerator
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:528.2325753
Heavy Atom Count:36
Complexity:804

Purity/Quality:

99%, ^*data from raw suppliers

LurasidoneHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s): F,T
Hazard Codes:F,T
Statements: 11-23/24/25-39/23/24/25
Safety Statements: 7-16-36/37-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC(C(C1)CN2CCN(CC2)C3=NSC4=CC=CC=C43)CN5C(=O)C6C7CCC(C7)C6C5=O.Cl
Isomeric SMILES:C1CC[C@H]([C@@H](C1)CN2CCN(CC2)C3=NSC4=CC=CC=C43)CN5C(=O)[C@H]6[C@@H]7CC[C@@H](C7)[C@H]6C5=O.Cl
Recent ClinicalTrials:The Safety and Effectiveness of Latuda? Post-marketing Surveillance in the Treatment of Chinese Schizophrenia Patients
Recent EU Clinical Trials:IMPACT OF STRUCTURAL AND MYELIN ABNORMALITIES ON COGNITIVE IMPAIRMENTS IN RECENT-ONSET SCHIZOPHRENIA – before and after lurasidone treatment
Recent NIPH Clinical Trials:Valuable interaction with cognitive remediation and optimal antipsychotics for recovery in schizophrenia
Uses Lurasidone is an atypical antipsychotic, inhibits Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C with IC50 of 1.68 nM, 2.03 nM, 0.495 nM, 6.75 nM and 10.8 nM, respectively An antipsychotic used for treatment of schizophrenia.

Technology Process of Lurasidone hydrochloride

There total 21 articles about Lurasidone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.3%

: 186204-37-5
(3aR,7aR)-4’-(benzo[d]isothiazol-3-yl)octahydrospiro[isoindole-2,1’-piperazin]-2-ium methanesulfonate

: 14805-29-9,1318027-24-5
(3aR,4S,7R,7aS)?4,7?methylene?1H?isoindole?1,3(2H)-dione

: 367514-88-3,139563-25-0
(3aR,4S,7R,7aS)-2-[((1R,2R)-2-{[4-(l1,2-benzisothiazol-3-yl)piperazin-1-yl]methyl}cyclohexyl)methyl]hexahydro-1H-4,7-methanisoindol-1,3-dione hydrochloride

Guidance literature:: (3aR,7aR)-4’-(benzo[d]isothiazol-3-yl)octahydrospiro[isoindole-2,1’-piperazin]-2-ium methanesulfonate; (3aR,4S,7R,7aS)?4,7?methylene?1H?isoindole?1,3(2H)-dione; With potassium carbonate; In toluene; at 105 ℃; for 15h; Industrial scale;

With hydrogenchloride; In isopropyl alcohol; Industrial scale;