tert-butyl {7-[2-(bis-benzyloxycarbonylmethyl-amino)-ethyl]-4,10-bis-tert-butoxycarbonylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl}-acetate

Base Information

• Chemical Name: tert-butyl {7-[2-(bis-benzyloxycarbonylmethyl-amino)-ethyl]-4,10-bis-tert-butoxycarbonylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl}-acetate
• CAS No.: 1093632-53-1
• Molecular Formula: C₄₆H₇₁N₅O₁₀
• Molecular Weight: 854.097
• Mol file: 1093632-53-1.mol

Synonyms:

Chemical Property of tert-butyl {7-[2-(bis-benzyloxycarbonylmethyl-amino)-ethyl]-4,10-bis-tert-butoxycarbonylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl}-acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl {7-[2-(bis-benzyloxycarbonylmethyl-amino)-ethyl]-4,10-bis-tert-butoxycarbonylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl}-acetate

There total 2 articles about tert-butyl {7-[2-(bis-benzyloxycarbonylmethyl-amino)-ethyl]-4,10-bis-tert-butoxycarbonylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl}-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2-[bis(benzyloxycarbonylmethyl)amino]ethyl bromide (146432-42-0) + 1,4,7-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododecane (122555-91-3) → tert-butyl {7-[2-(bis-benzyloxycarbonylmethyl-amino)-ethyl]-4,10-bis-tert-butoxycarbonylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl}-acetate (1093632-53-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 96h; Reflux;

DOI:10.1016/j.bmcl.2008.09.063

Reference yield:

→ tert-butyl {7-[2-(bis-benzyloxycarbonylmethyl-amino)-ethyl]-4,10-bis-tert-butoxycarbonylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl}-acetate (1093632-53-1)

Guidance literature:

upstream raw materials:

2-[bis(benzyloxycarbonylmethyl)amino]ethyl bromide

1,4,7-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododecane