Indeno[1,2-c]pyrazol-4(1H)-one, 3-(4-bromophenyl)-

Base Information

• Chemical Name: Indeno[1,2-c]pyrazol-4(1H)-one, 3-(4-bromophenyl)-
• CAS No.: 100007-87-2
• Molecular Formula: C16H9BrN2O
• Molecular Weight: 325.164
• Mol file: 100007-87-2.mol

Synonyms:

Chemical Property of Indeno[1,2-c]pyrazol-4(1H)-one, 3-(4-bromophenyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Indeno[1,2-c]pyrazol-4(1H)-one, 3-(4-bromophenyl)-

There total 2 articles about Indeno[1,2-c]pyrazol-4(1H)-one, 3-(4-bromophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-(4-bromophenyl)-1,4-dihydroindeno[1,2-c]pyrazole → 3-(4-bromophenyl)indeno[1,2-c]pyrazol-4(1H)-one (100007-87-2)

Guidance literature:

With oxygen; caesium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 7h;

DOI:10.1016/j.tetlet.2005.08.147

Reference yield:

2-(4-bromobenzoyl)-1H-indene-1,3(2H)-dione (19484-89-0) → 3-(4-bromophenyl)indeno[1,2-c]pyrazol-4(1H)-one (100007-87-2)

Guidance literature:

With hydrazine; In ethanol; at 90 ℃; Heating / reflux;

Reference yield: 85.0%

3-(4-bromophenyl)indeno[1,2-c]pyrazol-4(1H)-one (100007-87-2) + 3-Aminophenylboronic acid (30418-59-8,280563-63-5) → 3-(3'-amino-biphenyl-4-yl)-1H-indeno[1,2-c]pyrazol-4-one

Guidance literature:

With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; ethanol; water; at 160 ℃; microwave irradiation;

DOI:10.1016/j.tetlet.2005.08.147

upstream raw materials:

2-(4-bromobenzoyl)-1H-indene-1,3(2H)-dione

Refernces

• 1、 -. "FUSED TRI AND TETRA-CYCLIC PYRAZOLE KINASE INHIBITORS". Page 83. . Retrieved 2010/02/08.