Technology Process of 2',3'-O-methoxymethylene-N2-(4,4',4''-trimethoxytrityl)-7-methylguanosine-5'-diphosphate
There total 8 articles about 2',3'-O-methoxymethylene-N2-(4,4',4''-trimethoxytrityl)-7-methylguanosine-5'-diphosphate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
phosphoric acid; hydrogen sulfide; silver nitrate;
Multistep reaction;
1) pyridine, 1 h;
DOI:10.1016/0040-4039(88)85060-3
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 60 percent / N,N-dimethylaminopyridine, triethylamine / dimethylformamide / 0.5 h
2: 71 percent / butylamine-MeOH / 6 h / Ambient temperature
3: 77 percent / 1H-tetrazole, 1,2,3,5-tetramethylbenzenedisulphonyl dichloride / pyridine / 0.5 h
4: phosphinic acid, triethylamine / pyridine / 1 h / 40 °C
5: 85 percent / dimethylformamide / 2 h / Ambient temperature
6: tributylammonium phosphate, silver nitrate / pyridine / 1 h / Ambient temperature
With
1H-tetrazole; dmap; tri-n-butylammonium phosphate; 1,2,3,5-tetramethylbenzenedisulphonyl dichloride; butylamine-MeOH; hypophosphorous acid; silver nitrate; triethylamine;
In
pyridine; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 85 percent / dimethylformamide / 2 h / Ambient temperature
2: tributylammonium phosphate, silver nitrate / pyridine / 1 h / Ambient temperature
With
tri-n-butylammonium phosphate; silver nitrate;
In
pyridine; N,N-dimethyl-formamide;
