2,3-Dihydro-3-(4-chlorophenyl)-alpha-methyl-2-oxo-5-benzofuranacetic acid

Base Information

Chemical Name:2,3-Dihydro-3-(4-chlorophenyl)-alpha-methyl-2-oxo-5-benzofuranacetic acid
CAS No.:77143-71-6
Molecular Formula:C₁₇H₁₃ClO₄
Molecular Weight:316.741
Hs Code.:
DSSTox Substance ID:DTXSID30998401

Synonyms:BRN 4519394;2,3-Dihydro-3-(4-chlorophenyl)-alpha-methyl-2-oxo-5-benzofuranacetic acid;5-Benzofuranacetic acid, 2,3-dihydro-3-(4-chlorophenyl)-alpha-methyl-2-oxo-;77143-71-6;DTXSID30998401;LS-34862;2-[3-(4-Chlorophenyl)-2-oxo-2,3-dihydro-1-benzofuran-5-yl]propanoic acid

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,3-Dihydro-3-(4-chlorophenyl)-alpha-methyl-2-oxo-5-benzofuranacetic acid

Chemical Property:

Vapor Pressure:5.51E-09mmHg at 25°C
Boiling Point:452.7°C at 760 mmHg
Flash Point:227.6°C
Density:1.395g/cm³
XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:316.0502366
Heavy Atom Count:22
Complexity:444

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C1=CC2=C(C=C1)OC(=O)C2C3=CC=C(C=C3)Cl)C(=O)O

Technology Process of 2,3-Dihydro-3-(4-chlorophenyl)-alpha-methyl-2-oxo-5-benzofuranacetic acid

There total 3 articles about 2,3-Dihydro-3-(4-chlorophenyl)-alpha-methyl-2-oxo-5-benzofuranacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 77143-65-8
2-[3-(4-Chloro-phenyl)-2-oxo-2,3-dihydro-benzofuran-5-yl]-propionic acid methyl ester

: 77143-71-6
2-[3-(4-Chloro-phenyl)-2-oxo-2,3-dihydro-benzofuran-5-yl]-propionic acid

Guidance literature:: With sulfuric acid; Heating;

Reference yield:

: 65784-33-0
methyl 2-(4-hydroxyphenyl)propanoate

: 77143-71-6
2-[3-(4-Chloro-phenyl)-2-oxo-2,3-dihydro-benzofuran-5-yl]-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1) Na / 1) toluene, reflux, 8 h, 2) reflux, 8 h

2: 40 percent / conc. H₂SO₄ / 24 h / Ambient temperature

3: 80 percent / 50percent aq. H₂SO₄ / Heating

With sulfuric acid; sodium;

Reference yield:

: 77143-73-8
2-{4-[(4-Chloro-phenyl)-ethoxycarbonyl-methoxy]-phenyl}-propionic acid methyl ester

: 77143-71-6
2-[3-(4-Chloro-phenyl)-2-oxo-2,3-dihydro-benzofuran-5-yl]-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / conc. H₂SO₄ / 24 h / Ambient temperature

2: 80 percent / 50percent aq. H₂SO₄ / Heating

With sulfuric acid;