(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-N-{[(S)-1-benzyl-2-(N'-butyryl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-4-methanesulfinyl-butyramide

Base Information

Chemical Name:(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-N-{[(S)-1-benzyl-2-(N'-butyryl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-4-methanesulfinyl-butyramide
CAS No.:74085-70-4
Molecular Formula:C₂₉H₄₀N₆O₇S
Molecular Weight:616.739
Hs Code.:

(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-N-{[(S)-1-benzyl-2-(N'-butyryl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-4-methanesulfinyl-butyramide

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Chemical Property of (R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-N-{[(S)-1-benzyl-2-(N'-butyryl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-4-methanesulfinyl-butyramide

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Technology Process of (R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-N-{[(S)-1-benzyl-2-(N'-butyryl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-4-methanesulfinyl-butyramide

There total 11 articles about (R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-N-{[(S)-1-benzyl-2-(N'-butyryl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-4-methanesulfinyl-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3956-78-3
CbzGly-L-PheOEt

: 74085-70-4
(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-N-{[(S)-1-benzyl-2-(N'-butyryl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-4-methanesulfinyl-butyramide

Guidance literature:: Multi-step reaction with 8 steps

1: hydrogen / Pd-black / methanol

2: acetonitrile / Ambient temperature

3: 30percent agueous H₂O₂ / aq. HCl / 10 h / Ambient temperature

4: TFA / 20 h / Ambient temperature

5: TEA / acetonitrile

6: 85 percent / NH₂NH₂*H₂O / ethanol; dimethylformamide / 48 h / Ambient temperature

7: 73 percent / HOBT, DCC / dimethylformamide / 1.) 0 deg C, 5 h, 2.) r.t.

8: 110 mg / methanesulfonic acid / various solvent(s) / 0.5 h / Ambient temperature

With methanesulfonic acid; TEA; hydrogen; dihydrogen peroxide; benzotriazol-1-ol; hydrazine hydrate; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium; In hydrogenchloride; methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.29.3646

Reference yield:

: 3182-93-2
(L)-phenylalanine ethyl ester hydrochloride

: 74085-70-4
(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-N-{[(S)-1-benzyl-2-(N'-butyryl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-4-methanesulfinyl-butyramide

Guidance literature:: Multi-step reaction with 9 steps

1: TEA / acetonitrile / Ambient temperature

2: hydrogen / Pd-black / methanol

3: acetonitrile / Ambient temperature

4: 30percent agueous H₂O₂ / aq. HCl / 10 h / Ambient temperature

5: TFA / 20 h / Ambient temperature

6: TEA / acetonitrile

7: 85 percent / NH₂NH₂*H₂O / ethanol; dimethylformamide / 48 h / Ambient temperature

8: 73 percent / HOBT, DCC / dimethylformamide / 1.) 0 deg C, 5 h, 2.) r.t.

9: 110 mg / methanesulfonic acid / various solvent(s) / 0.5 h / Ambient temperature

With methanesulfonic acid; TEA; hydrogen; dihydrogen peroxide; benzotriazol-1-ol; hydrazine hydrate; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium; In hydrogenchloride; methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.29.3646