1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-(<(dimethylamino)methylidene>amino)-1H-imidazo<4,5-c>pyridin-5(5H)-one 3'-<(2-cyanoethyl)N,N-diisopropylphosphoramidite>

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Chemical Name:1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-(<(dimethylamino)methylidene>amino)-1H-imidazo<4,5-c>pyridin-5(5H)-one 3'-<(2-cyanoethyl)N,N-diisopropylphosphoramidite>
CAS No.:139212-54-7
Molecular Formula:C₄₄H₅₄N₇O₇P
Molecular Weight:823.929
Hs Code.:

1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-(<(dimethylamino)methylidene>amino)-1H-imidazo<4,5-c>pyridin-5(5H)-one 3'-<(2-cyanoethyl)N,N-diisopropylphosphoramidite>

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Chemical Property of 1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-(<(dimethylamino)methylidene>amino)-1H-imidazo<4,5-c>pyridin-5(5H)-one 3'-<(2-cyanoethyl)N,N-diisopropylphosphoramidite>

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Technology Process of 1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-(<(dimethylamino)methylidene>amino)-1H-imidazo<4,5-c>pyridin-5(5H)-one 3'-<(2-cyanoethyl)N,N-diisopropylphosphoramidite>

There total 5 articles about 1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-(<(dimethylamino)methylidene>amino)-1H-imidazo<4,5-c>pyridin-5(5H)-one 3'-<(2-cyanoethyl)N,N-diisopropylphosphoramidite> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.4%

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 139212-52-5
1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-(<(dimethylamino)methylidene>amino)-1H-imidazo<4,5-c>pyridin-4(5H)-one

: 139212-54-7,139212-55-8
1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-(<(dimethylamino)methylidene>amino)-1H-imidazo<4,5-c>pyridin-5(5H)-one 3'-<(2-cyanoethyl)N,N-diisopropylphosphoramidite>

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1002/hlca.19910740821

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 139212-54-7,139212-55-8
1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-(<(dimethylamino)methylidene>amino)-1H-imidazo<4,5-c>pyridin-5(5H)-one 3'-<(2-cyanoethyl)N,N-diisopropylphosphoramidite>

Guidance literature:: Multi-step reaction with 2 steps

1: 70.8 percent / pyridine, 4-(dimethylamino)pyridine / 3 h / Ambient temperature

2: 46.4 percent / i-Pr₂EtN / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1002/hlca.19910740821

Reference yield:

: 87202-41-3
6-amino-1-(2'-deoxy-β-D-erythro-pentofuranosyl)-1H-imidazo<4,5-c>pyridin-4(5H)-one

: 139212-54-7,139212-55-8
1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-(<(dimethylamino)methylidene>amino)-1H-imidazo<4,5-c>pyridin-5(5H)-one 3'-<(2-cyanoethyl)N,N-diisopropylphosphoramidite>

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / dimethylformamide / 24 h / Ambient temperature

2: 70.8 percent / pyridine, 4-(dimethylamino)pyridine / 3 h / Ambient temperature

3: 46.4 percent / i-Pr₂EtN / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19910740821