(R)-4-[(R)-2-(Toluene-4-sulfonyloxymethyl)-butyl]-2,3,3a,4,5,7-hexahydro-1H-pyrrolo[2,3-d]carbazole-6-carboxylic acid methyl ester

Base Information

• Chemical Name: (R)-4-[(R)-2-(Toluene-4-sulfonyloxymethyl)-butyl]-2,3,3a,4,5,7-hexahydro-1H-pyrrolo[2,3-d]carbazole-6-carboxylic acid methyl ester
• CAS No.: 121074-32-6
• Molecular Formula: C₂₈H₃₄N₂O₅S
• Molecular Weight: 510.654
• Mol file: 121074-32-6.mol

Synonyms:

Chemical Property of (R)-4-[(R)-2-(Toluene-4-sulfonyloxymethyl)-butyl]-2,3,3a,4,5,7-hexahydro-1H-pyrrolo[2,3-d]carbazole-6-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-4-[(R)-2-(Toluene-4-sulfonyloxymethyl)-butyl]-2,3,3a,4,5,7-hexahydro-1H-pyrrolo[2,3-d]carbazole-6-carboxylic acid methyl ester

There total 6 articles about (R)-4-[(R)-2-(Toluene-4-sulfonyloxymethyl)-butyl]-2,3,3a,4,5,7-hexahydro-1H-pyrrolo[2,3-d]carbazole-6-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Nb-benzyl-21-(tosyloxy)-D-seco-Ψ-vincadifformine (109704-80-5,121153-59-1,121153-60-4) → (R)-4-[(R)-2-(Toluene-4-sulfonyloxymethyl)-butyl]-2,3,3a,4,5,7-hexahydro-1H-pyrrolo[2,3-d]carbazole-6-carboxylic acid methyl ester (121074-32-6,121153-92-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; for 4h; under 760 Torr;

DOI:10.1021/jo00275a029

Reference yield:

Nb-benzyl-21-(tosyloxy)-D-seco-Ψ-vincadifformine (109704-80-5,121153-59-1,121153-60-4) → (R)-4-[(S)-2-(Toluene-4-sulfonyloxymethyl)-butyl]-2,3,3a,4,5,7-hexahydro-1H-pyrrolo[2,3-d]carbazole-6-carboxylic acid methyl ester (121074-32-6,121153-92-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; for 4h; under 760 Torr;

DOI:10.1021/jo00275a029

Reference yield:

Nb-benzyl-21-hydroxy-D-seco-Ψ-vincadifformine (109704-79-2,121153-57-9,121153-58-0,121153-88-6,121153-89-7,121153-90-0,121153-91-1) → (R)-4-[(S)-2-(Toluene-4-sulfonyloxymethyl)-butyl]-2,3,3a,4,5,7-hexahydro-1H-pyrrolo[2,3-d]carbazole-6-carboxylic acid methyl ester (121074-32-6,121153-92-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.391 g / 4-(dimethylamino)pyridine, pyridine / 1.) 0 deg C, 4 h, 2.) 4 deg C, 24 h

2: H₂ / 10percent Pd/C / acetic acid / 4 h / 760 Torr

With pyridine; dmap; hydrogen; palladium on activated charcoal; In acetic acid;

DOI:10.1021/jo00275a029

upstream raw materials:

N^b-benzyl-21-(tosyloxy)-D-seco-Ψ-vincadifformine

N^b-benzyl-21-hydroxy-D-seco-Ψ-vincadifformine

p-toluenesulfonyl chloride

N^b-benzyl-21-(tosyloxy)-D-seco-Ψ-vincadifformine

Downstream raw materials:

(+/-)-20-Epipseudovincadifformine

(+/-)-14-Epipseudovincadifformine

C₄₆H₅₈N₄O₈

C₂₁H₂₈N₂O₂