4-<<<4-(trans-2-nitroethenyl)phenyl>oxy>sulfonyl>benzoyl-L-alanyl-L-alanine <ethylene>amide

Base Information

• Chemical Name: 4-<<<4-(trans-2-nitroethenyl)phenyl>oxy>sulfonyl>benzoyl-L-alanyl-L-alanine <ethylene>amide
• CAS No.: 134360-47-7
• Molecular Formula: C₂₈H₃₅N₅O₁₀S
• Molecular Weight: 633.679
• Mol file: 134360-47-7.mol

Synonyms:

Chemical Property of 4-<<<4-(trans-2-nitroethenyl)phenyl>oxy>sulfonyl>benzoyl-L-alanyl-L-alanine <ethylene>amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-<<<4-(trans-2-nitroethenyl)phenyl>oxy>sulfonyl>benzoyl-L-alanyl-L-alanine <ethylene>amide

There total 3 articles about 4-<<<4-(trans-2-nitroethenyl)phenyl>oxy>sulfonyl>benzoyl-L-alanyl-L-alanine <ethylene>amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N-(tert-butyloxycarbonyl)-1,2-diaminoethane toluensulfonic acid salt (112670-29-8) + 4-<<<4-(trans-2-nitroethenyl)phenyl>oxy>sulfonyl>benzoyl-L-alanyl-L-alanine N-hydroxysuccinimide ester → 4-<<<4-(trans-2-nitroethenyl)phenyl>oxy>sulfonyl>benzoyl-L-alanyl-L-alanine <ethylene>amide (134360-47-7)

Guidance literature:

With methoxybenzene; trifluoroacetic acid; for 0.25h; Ambient temperature;

Reference yield:

4-<<<4-(trans-2-nitroethenyl)phenyl>oxy>sulfonyl>benzoyl-L-alanyl-L-alanine (134360-46-6) → 4-<<<4-(trans-2-nitroethenyl)phenyl>oxy>sulfonyl>benzoyl-L-alanyl-L-alanine <ethylene>amide (134360-47-7)

Guidance literature:

Multi-step reaction with 2 steps

1: DCC / 1,2-dimethoxy-ethane / 1.) 0 deg C, 2.5 h, 2.) RT, 16 h

2: 220 mg / 4-ethylmorpholine / 1,2-dimethoxy-ethane / 26 h

With N-ethylmorpholine;; dicyclohexyl-carbodiimide; In 1,2-dimethoxyethane;

DOI:10.1021/jm00112a003

Reference yield:

4-<<<4-(trans-2-nitroethenyl)phenyl>oxy>sulfonyl>benzoyl-L-alanyl-L-alanine tert-butyl ester (134360-45-5) → 4-<<<4-(trans-2-nitroethenyl)phenyl>oxy>sulfonyl>benzoyl-L-alanyl-L-alanine <ethylene>amide (134360-47-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 104 mg / CF₃COOH / 3.5 h / Ambient temperature

2: DCC / 1,2-dimethoxy-ethane / 1.) 0 deg C, 2.5 h, 2.) RT, 16 h

3: 220 mg / 4-ethylmorpholine / 1,2-dimethoxy-ethane / 26 h

With N-ethylmorpholine;; dicyclohexyl-carbodiimide; trifluoroacetic acid; In 1,2-dimethoxyethane;

DOI:10.1021/jm00112a003

upstream raw materials:

N-(tert-butyloxycarbonyl)-1,2-diaminoethane toluensulfonic acid salt

4-<<<4-(trans-2-nitroethenyl)phenyl>oxy>sulfonyl>benzoyl-L-alanyl-L-alanine

4-<<<4-(trans-2-nitroethenyl)phenyl>oxy>sulfonyl>benzoyl-L-alanyl-L-alanine tert-butyl ester

Downstream raw materials:

4-<<<4-(trans-2-nitroethenyl)phenyl>oxy>sulfonyl>benzoyl-L-alanyl-L-alanine (aminoethylene)amide hydrochloride