1-<2'-O-Phenoxythiocarbonyl-3',5'-O-(tetraisopropyldisiloxan-1,3-diyl)-β-D-ribofuranosyl>-5-(tert.butylamino)-tetrazol

Base Information

• Chemical Name: 1-<2'-O-Phenoxythiocarbonyl-3',5'-O-(tetraisopropyldisiloxan-1,3-diyl)-β-D-ribofuranosyl>-5-(tert.butylamino)-tetrazol
• CAS No.: 112105-22-3
• Molecular Formula: C₂₉H₄₉N₅O₆SSi₂
• Molecular Weight: 651.975
• Mol file: 112105-22-3.mol

Synonyms:

Chemical Property of 1-<2'-O-Phenoxythiocarbonyl-3',5'-O-(tetraisopropyldisiloxan-1,3-diyl)-β-D-ribofuranosyl>-5-(tert.butylamino)-tetrazol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<2'-O-Phenoxythiocarbonyl-3',5'-O-(tetraisopropyldisiloxan-1,3-diyl)-β-D-ribofuranosyl>-5-(tert.butylamino)-tetrazol

There total 5 articles about 1-<2'-O-Phenoxythiocarbonyl-3',5'-O-(tetraisopropyldisiloxan-1,3-diyl)-β-D-ribofuranosyl>-5-(tert.butylamino)-tetrazol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3R,4S,5R)-2-azido-5-hydroxymethyl-tetrahydro-furan-3,4-diol (51970-31-1) → 1-<2'-O-Phenoxythiocarbonyl-3',5'-O-(tetraisopropyldisiloxan-1,3-diyl)-β-D-ribofuranosyl>-5-(tert.butylamino)-tetrazol (112105-22-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 89 percent / imidazole / dimethylformamide / 12 h

2: toluene / 1 h / 80 °C

3: toluene / 60 °C

4: HN₃ / toluene / 12 h

5: 73 percent / 4-dimethylaminopyridine / acetonitrile / Ambient temperature

With 1H-imidazole; dmap; tris-(2-chloro-ethyl)-amine; In N,N-dimethyl-formamide; toluene; acetonitrile;

DOI:10.1007/BF00810753

Reference yield:

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane (69304-37-6) → 1-<2'-O-Phenoxythiocarbonyl-3',5'-O-(tetraisopropyldisiloxan-1,3-diyl)-β-D-ribofuranosyl>-5-(tert.butylamino)-tetrazol (112105-22-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 89 percent / imidazole / dimethylformamide / 12 h

2: toluene / 1 h / 80 °C

3: toluene / 60 °C

4: HN₃ / toluene / 12 h

5: 73 percent / 4-dimethylaminopyridine / acetonitrile / Ambient temperature

With 1H-imidazole; dmap; tris-(2-chloro-ethyl)-amine; In N,N-dimethyl-formamide; toluene; acetonitrile;

DOI:10.1007/BF00810753

Reference yield:

3',5'-O-(Tetraisopropyldisiloxan-1,3-diyl)-β-D-ribofuranosylazid (112105-19-8) → 1-<2'-O-Phenoxythiocarbonyl-3',5'-O-(tetraisopropyldisiloxan-1,3-diyl)-β-D-ribofuranosyl>-5-(tert.butylamino)-tetrazol (112105-22-3)

Guidance literature:

Multi-step reaction with 4 steps

1: toluene / 1 h / 80 °C

2: toluene / 60 °C

3: HN₃ / toluene / 12 h

4: 73 percent / 4-dimethylaminopyridine / acetonitrile / Ambient temperature

With dmap; tris-(2-chloro-ethyl)-amine; In toluene; acetonitrile;

DOI:10.1007/BF00810753

upstream raw materials:

(2R,3R,4S,5R)-2-azido-5-hydroxymethyl-tetrahydro-furan-3,4-diol

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

3',5'-O-(Tetraisopropyldisiloxan-1,3-diyl)-β-D-ribofuranosylazid