C₃₀H₂₈F₃N₅O₂

Base Information

• Chemical Name: C₃₀H₂₈F₃N₅O₂
• CAS No.: 1093395-81-3
• Molecular Formula: C₃₀H₂₈F₃N₅O₂
• Molecular Weight: 547.58
• Mol file: 1093395-81-3.mol

Synonyms:

Chemical Property of C₃₀H₂₈F₃N₅O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₀H₂₈F₃N₅O₂

There total 7 articles about C₃₀H₂₈F₃N₅O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-amino-5-bromo-4-hydroxybenzonitrile (862730-24-3) → C30H28F3N5O2 (1093395-81-3)

Guidance literature:

Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / toluene / 110 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene

3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol

4: water; lithium hydroxide / tetrahydrofuran; methanol

5: oxalyl dichloride; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; palladium 10% on activated carbon; water; hydrogen; sodium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 2: Suzuki coupling;

DOI:10.1016/j.bmcl.2010.11.090

Reference yield:

methyl 4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoate (1093395-68-6) → C30H28F3N5O2 (1093395-81-3)

Guidance literature:

Multi-step reaction with 2 steps

1: water; lithium hydroxide / tetrahydrofuran; methanol

2: oxalyl dichloride; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide

With oxalyl dichloride; water; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2010.11.090

Reference yield:

methyl 4-(7-bromo-5-cyano-1,3-benzoxazol-2-yl)benzoate (1093395-65-3) → C30H28F3N5O2 (1093395-81-3)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol

3: water; lithium hydroxide / tetrahydrofuran; methanol

4: oxalyl dichloride; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; palladium 10% on activated carbon; water; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 1: Suzuki coupling;

DOI:10.1016/j.bmcl.2010.11.090

upstream raw materials:

3-amino-5-bromo-4-hydroxybenzonitrile

methyl 4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoate

methyl 4-(7-bromo-5-cyano-1,3-benzoxazol-2-yl)benzoate

methyl 4-(5-cyano-7-isopropenyl-1,3-benzoxazol-2-yl)benzoate