(S)-7-[3-(1-t-butoxycarbonylamino-1-methylethyl)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Base Information

Chemical Name:(S)-7-[3-(1-t-butoxycarbonylamino-1-methylethyl)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
CAS No.:143158-48-9
Molecular Formula:C₂₆H₃₄FN₃O₆
Molecular Weight:503.571
Hs Code.:

(S)-7-[3-(1-t-butoxycarbonylamino-1-methylethyl)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

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Chemical Property of (S)-7-[3-(1-t-butoxycarbonylamino-1-methylethyl)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

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Technology Process of (S)-7-[3-(1-t-butoxycarbonylamino-1-methylethyl)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

There total 4 articles about (S)-7-[3-(1-t-butoxycarbonylamino-1-methylethyl)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: -α,α-dimethyl-1-(1-phenylethyl)-3-pyrrolidineacetic acid

: 143158-48-9
(S)-7-[3-(1-t-butoxycarbonylamino-1-methylethyl)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 3A molecular sieves, Et₃N, 2.) diphenyl phosphorazidate / 1.) 1 h, 2.) reflux, 30 h

2: 85 percent / H₂ / 20percent Pd/C / methanol / 14 h / 2585.7 Torr

3: diisopropylethylamine / acetonitrile / 18 h / Heating

With 3 A molecular sieve; diphenyl phosphoryl azide; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; acetonitrile;
DOI:10.1021/jm00032a005

Reference yield:

: 153566-72-4
1,1-dimethylethyl -<1-methyl-1-<1-(1-phenylethyl)-3-pyrrolidinyl>ethyl>carbamate

: 143158-48-9
(S)-7-[3-(1-t-butoxycarbonylamino-1-methylethyl)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / H₂ / 20percent Pd/C / methanol / 14 h / 2585.7 Torr

2: diisopropylethylamine / acetonitrile / 18 h / Heating

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; acetonitrile;
DOI:10.1021/jm00032a005