Technology Process of 9-adenine
There total 10 articles about 9-adenine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 50 percent / POCl3, Zn-Cu couple / diethyl ether / 18 h / Heating
2: 68 percent / Zn, CH3COOH / 4 h / Heating
3: L-Selectride / tetrahydrofuran / -78 °C
4: 88 percent / PPh3, diethyl azodicarboxylate / tetrahydrofuran / 12 h / Ambient temperature
5: 1) 3-chloroperbenzoic acid, 2) NH3 / 1) CH2Cl2, room temperature, 1 h, 2) 1,4-dioxane, room temperature, 20 h
With
ammonia; L-Selectride; copper; acetic acid; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; zinc; diethylazodicarboxylate; trichlorophosphate;
In
tetrahydrofuran; diethyl ether;
DOI:10.1039/P19950002281
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 68 percent / Zn, CH3COOH / 4 h / Heating
2: L-Selectride / tetrahydrofuran / -78 °C
3: 88 percent / PPh3, diethyl azodicarboxylate / tetrahydrofuran / 12 h / Ambient temperature
4: 1) 3-chloroperbenzoic acid, 2) NH3 / 1) CH2Cl2, room temperature, 1 h, 2) 1,4-dioxane, room temperature, 20 h
With
ammonia; L-Selectride; acetic acid; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; zinc; diethylazodicarboxylate;
In
tetrahydrofuran;
DOI:10.1039/P19950002281
- Guidance literature:
-
Multi-step reaction with 3 steps
1: L-Selectride / tetrahydrofuran / -78 °C
2: 88 percent / PPh3, diethyl azodicarboxylate / tetrahydrofuran / 12 h / Ambient temperature
3: 1) 3-chloroperbenzoic acid, 2) NH3 / 1) CH2Cl2, room temperature, 1 h, 2) 1,4-dioxane, room temperature, 20 h
With
ammonia; L-Selectride; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran;
DOI:10.1039/P19950002281