Hs 27

Base Information

• Chemical Name: Hs 27
• CAS No.: 1562024-11-6
• Molecular Formula: C₅₂H₆₀N₆O₁₂S
• Molecular Weight: 993.147
• Mol file: 1562024-11-6.mol

Synonyms:

Chemical Property of Hs 27

Chemical Property:

• Boiling Point: 1095.1±75.0 °C(Predicted)
• PKA: 9.33±0.20(Predicted)
• Density: 1.39±0.1 g/cm3(Predicted)
• Storage Temp.: -196°C

Purity/Quality:

97% ^*data from raw suppliers

HS-27 90% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Hs 27

There total 5 articles about Hs 27 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

fluorescein isothiocyanate (3326-32-7,27072-45-3) + 2-((19-amino-4,7,10,13,16-pentaoxanonadecyl)amino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide (1377297-20-5) → 2-((1-((3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9,-xanthen]-5-yl)amino)-1-thioxo-6,9,12,15,18-pentaoxa-2-azahenicosan-21-yl)amino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide (1562024-11-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ethanol;

Reference yield:

2-acetyldimedone (1755-15-3) → 2-((1-((3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9,-xanthen]-5-yl)amino)-1-thioxo-6,9,12,15,18-pentaoxa-2-azahenicosan-21-yl)amino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide (1562024-11-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetic acid / methanol / 72 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.33 h / 90 °C

2.2: 0.17 h

3.1: N-ethyl-N,N-diisopropylamine / ethanol

With acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dimethyl sulfoxide;

Reference yield:

dimedone (126-81-8) → 2-((1-((3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9,-xanthen]-5-yl)amino)-1-thioxo-6,9,12,15,18-pentaoxa-2-azahenicosan-21-yl)amino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide (1562024-11-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 24 h

2.1: acetic acid / methanol / 72 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.33 h / 90 °C

3.2: 0.17 h

4.1: N-ethyl-N,N-diisopropylamine / ethanol

With dmap; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; dimethyl sulfoxide;

upstream raw materials:

fluorescein isothiocyanate

2-((19-amino-4,7,10,13,16-pentaoxanonadecyl)amino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide

2-acetyldimedone

dimedone