Technology Process of 7-chloro-2-ethyl-N-(4-(4-methylpiperazin-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide
There total 8 articles about 7-chloro-2-ethyl-N-(4-(4-methylpiperazin-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: lithium hydroxide; water / ethanol / 20 °C / Inert atmosphere
2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h / Inert atmosphere
With
water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide;
In
ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm5003606
- Guidance literature:
-
Multi-step reaction with 4 steps
1: N-Bromosuccinimide; ammonium acetate / diethyl ether / 6 h / 20 °C / Inert atmosphere
2: ethanol / Reflux; Inert atmosphere
3: lithium hydroxide; water / ethanol / 20 °C / Inert atmosphere
4: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h / Inert atmosphere
With
N-Bromosuccinimide; ammonium acetate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide;
In
diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm5003606
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate / dimethyl sulfoxide / 90 - 120 °C / Inert atmosphere
2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Reflux; Inert atmosphere
3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h / Inert atmosphere
With
lithium aluminium tetrahydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm5003606