(S)-2-(3-tert-Butoxycarbonylamino-2,2-dimethyl-propionylamino)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

Base Information

Chemical Name:(S)-2-(3-tert-Butoxycarbonylamino-2,2-dimethyl-propionylamino)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester
CAS No.:211678-37-4
Molecular Formula:C₄₃H₅₇Cl₄N₃O₉
Molecular Weight:901.752
Hs Code.:

(S)-2-(3-tert-Butoxycarbonylamino-2,2-dimethyl-propionylamino)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

Synonyms:

Suppliers and Price of (S)-2-(3-tert-Butoxycarbonylamino-2,2-dimethyl-propionylamino)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-2-(3-tert-Butoxycarbonylamino-2,2-dimethyl-propionylamino)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-(3-tert-Butoxycarbonylamino-2,2-dimethyl-propionylamino)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

There total 1 articles about (S)-2-(3-tert-Butoxycarbonylamino-2,2-dimethyl-propionylamino)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-2-Amino-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester; compound with trifluoro-acetic acid

: 180181-02-6
3-(tert-Butoxycarbonyl)amino-2,2-dimethylpropanoic Acid

: 211678-37-4
(S)-2-(3-tert-Butoxycarbonylamino-2,2-dimethyl-propionylamino)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; Yield given. Multistep reaction; 1.) DMF, THF, 25 deg C, 15 min, 2.) DMF, THF, 25 deg C, 15 h;
DOI:10.1021/jo980536r

Reference yield:

: 211678-37-4
(S)-2-(3-tert-Butoxycarbonylamino-2,2-dimethyl-propionylamino)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

: (E)-(3S,10R,16S)-10-(3-Chloro-4-methoxy-benzyl)-3-isobutyl-6,6-dimethyl-16-[(S)-1-((2S,3S)-3-phenyl-oxiranyl)-ethyl]-1-oxa-4,8,11-triaza-cyclohexadec-13-ene-2,5,9,12-tetraone

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Zn, AcOH, 2.) CF₃COOH / 1.) sonication, 45 min, then room temp., 30 min, 2.) room temp., 2 h

2: 83 percent / diisopropylethylamine, pentafluorophenyl diphenylphosphinate / dimethylformamide / 4 h / Ambient temperature

3: m-chloroperbenzoic acid / CH₂Cl₂ / 17 h / 25 °C

With pentafluorophenyl diphenyl-phosphinate; acetic acid; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; zinc; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo980536r

Reference yield:

: 211678-37-4
(S)-2-(3-tert-Butoxycarbonylamino-2,2-dimethyl-propionylamino)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

: (E)-(3S,10R,16S)-10-(3-Chloro-4-methoxy-benzyl)-3-isobutyl-6,6-dimethyl-16-[(S)-1-((2R,3R)-3-phenyl-oxiranyl)-ethyl]-1-oxa-4,8,11-triaza-cyclohexadec-13-ene-2,5,9,12-tetraone

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Zn, AcOH, 2.) CF₃COOH / 1.) sonication, 45 min, then room temp., 30 min, 2.) room temp., 2 h

2: 83 percent / diisopropylethylamine, pentafluorophenyl diphenylphosphinate / dimethylformamide / 4 h / Ambient temperature

3: m-chloroperbenzoic acid / CH₂Cl₂ / 17 h / 25 °C

With pentafluorophenyl diphenyl-phosphinate; acetic acid; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; zinc; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo980536r