C₂₇H₂₅FN₂O₆S

Base Information

Chemical Name:C₂₇H₂₅FN₂O₆S
CAS No.:1374229-83-0
Molecular Formula:C₂₇H₂₅FN₂O₆S
Molecular Weight:524.57
Hs Code.:

C<sub>27</sub>H<sub>25</sub>FN<sub>2</sub>O<sub>6</sub>S

Synonyms:

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Chemical Property of C₂₇H₂₅FN₂O₆S

Chemical Property:

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Technology Process of C₂₇H₂₅FN₂O₆S

There total 16 articles about C₂₇H₂₅FN₂O₆S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 26510-95-2
ethyl 4-Bromobenzoylacetate

: 1374229-84-1
C₂₇H₂₅FN₂O₆S

: 1374229-83-0
C₂₇H₂₅FN₂O₆S

Guidance literature:: Multi-step reaction with 15 steps

1.1: zinc(II) chloride / N,N-dimethyl-formamide / 3.5 h / 105 °C

2.1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 0.33 h / 20 °C

2.2: 4 h / 80 °C

3.1: nitric acid / dichloromethane / 1.5 h / 0 - 20 °C

4.1: potassium phosphate / palladium diacetate; tert-butyl XPhos / toluene / 2 h / 100 °C / Inert atmosphere

5.1: boron trichloride / dichloromethane / -78 - -40 °C

6.1: triethylamine / dmap / dichloromethane / 1 h / 0 - 20 °C

7.1: sodium acetate / (diphenylphosphin)ferrocene; palladium diacetate / acetonitrile / 2 h / 100 °C / Inert atmosphere

8.1: hydrogenchloride; water / tetrahydrofuran / 1 h / Reflux

9.1: tin(II) chloride dihdyrate / ethyl acetate / 1 h / 80 °C

9.2: 20 °C / pH 8 - 9

10.1: pyridine / 2 h / 0 - 30 °C

11.1: sodium tetrahydroborate / tetrahydrofuran / 0.5 h / 0 °C

12.1: sodium hydride / dichloromethane; paraoil / 15 h / 0 - 20 °C

13.1: water; lithium hydroxide / tetrahydrofuran; methanol / 12 h / 80 °C

13.2: 20 °C / pH 2 - 3

14.1: HATU / N,N-dimethyl-formamide / 1 h / 20 °C

14.2: 1 h / 20 °C

15.1: Daicel CHIRALPAK AS-H column / methanol; carbon dioxide / Resolution of racemate

With pyridine; hydrogenchloride; sodium tetrahydroborate; potassium phosphate; tin(II) chloride dihdyrate; water; nitric acid; sodium acetate; boron trichloride; sodium hydride; caesium carbonate; triethylamine; HATU; zinc(II) chloride; lithium hydroxide; dmap; (diphenylphosphin)ferrocene; palladium diacetate; tert-butyl XPhos; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; carbon dioxide; paraoil; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 5010-37-7
2-(4-bromo-phenyl)-5-hydroxy-benzofuran-3-carboxylic acid ethyl ester

: 1374229-84-1
C₂₇H₂₅FN₂O₆S

: 1374229-83-0
C₂₇H₂₅FN₂O₆S

Guidance literature:: Multi-step reaction with 14 steps

1.1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 0.33 h / 20 °C

1.2: 4 h / 80 °C

2.1: nitric acid / dichloromethane / 1.5 h / 0 - 20 °C

3.1: potassium phosphate / palladium diacetate; tert-butyl XPhos / toluene / 2 h / 100 °C / Inert atmosphere

4.1: boron trichloride / dichloromethane / -78 - -40 °C

5.1: triethylamine / dmap / dichloromethane / 1 h / 0 - 20 °C

6.1: sodium acetate / (diphenylphosphin)ferrocene; palladium diacetate / acetonitrile / 2 h / 100 °C / Inert atmosphere

7.1: hydrogenchloride; water / tetrahydrofuran / 1 h / Reflux

8.1: tin(II) chloride dihdyrate / ethyl acetate / 1 h / 80 °C

8.2: 20 °C / pH 8 - 9

9.1: pyridine / 2 h / 0 - 30 °C

10.1: sodium tetrahydroborate / tetrahydrofuran / 0.5 h / 0 °C

11.1: sodium hydride / dichloromethane; paraoil / 15 h / 0 - 20 °C

12.1: water; lithium hydroxide / tetrahydrofuran; methanol / 12 h / 80 °C

12.2: 20 °C / pH 2 - 3

13.1: HATU / N,N-dimethyl-formamide / 1 h / 20 °C

13.2: 1 h / 20 °C

14.1: Daicel CHIRALPAK AS-H column / methanol; carbon dioxide / Resolution of racemate

With pyridine; hydrogenchloride; sodium tetrahydroborate; potassium phosphate; tin(II) chloride dihdyrate; water; nitric acid; sodium acetate; boron trichloride; sodium hydride; caesium carbonate; triethylamine; HATU; lithium hydroxide; dmap; (diphenylphosphin)ferrocene; palladium diacetate; tert-butyl XPhos; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; carbon dioxide; paraoil; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 691856-79-8
ethyl 2-(4-bromophenyl)-5-isopropoxybenzofuran-3-carboxylate

: 1374229-84-1
C₂₇H₂₅FN₂O₆S

: 1374229-83-0
C₂₇H₂₅FN₂O₆S

Guidance literature:: Multi-step reaction with 13 steps

1.1: nitric acid / dichloromethane / 1.5 h / 0 - 20 °C

2.1: potassium phosphate / palladium diacetate; tert-butyl XPhos / toluene / 2 h / 100 °C / Inert atmosphere

3.1: boron trichloride / dichloromethane / -78 - -40 °C

4.1: triethylamine / dmap / dichloromethane / 1 h / 0 - 20 °C

5.1: sodium acetate / (diphenylphosphin)ferrocene; palladium diacetate / acetonitrile / 2 h / 100 °C / Inert atmosphere

6.1: hydrogenchloride; water / tetrahydrofuran / 1 h / Reflux

7.1: tin(II) chloride dihdyrate / ethyl acetate / 1 h / 80 °C

7.2: 20 °C / pH 8 - 9

8.1: pyridine / 2 h / 0 - 30 °C

9.1: sodium tetrahydroborate / tetrahydrofuran / 0.5 h / 0 °C

10.1: sodium hydride / dichloromethane; paraoil / 15 h / 0 - 20 °C

11.1: water; lithium hydroxide / tetrahydrofuran; methanol / 12 h / 80 °C

11.2: 20 °C / pH 2 - 3

12.1: HATU / N,N-dimethyl-formamide / 1 h / 20 °C

12.2: 1 h / 20 °C

13.1: Daicel CHIRALPAK AS-H column / methanol; carbon dioxide / Resolution of racemate

With pyridine; hydrogenchloride; sodium tetrahydroborate; potassium phosphate; tin(II) chloride dihdyrate; water; nitric acid; sodium acetate; boron trichloride; sodium hydride; triethylamine; HATU; lithium hydroxide; dmap; (diphenylphosphin)ferrocene; palladium diacetate; tert-butyl XPhos; In tetrahydrofuran; methanol; dichloromethane; carbon dioxide; paraoil; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;