(1R,2S,5S)-2-[(1R,3aS,4S,5S,7aR)-4-Hydroxy-7a-methyl-1-((Z)-(R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-5-yl]-5-methoxymethoxy-2-methyl-cyclohexanecarbonitrile

Base Information

• Chemical Name: (1R,2S,5S)-2-[(1R,3aS,4S,5S,7aR)-4-Hydroxy-7a-methyl-1-((Z)-(R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-5-yl]-5-methoxymethoxy-2-methyl-cyclohexanecarbonitrile
• CAS No.: 99598-74-0
• Molecular Formula: C₂₉H₄₉NO₃
• Molecular Weight: 459.713
• Mol file: 99598-74-0.mol

Synonyms:

Chemical Property of (1R,2S,5S)-2-[(1R,3aS,4S,5S,7aR)-4-Hydroxy-7a-methyl-1-((Z)-(R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-5-yl]-5-methoxymethoxy-2-methyl-cyclohexanecarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S,5S)-2-[(1R,3aS,4S,5S,7aR)-4-Hydroxy-7a-methyl-1-((Z)-(R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-5-yl]-5-methoxymethoxy-2-methyl-cyclohexanecarbonitrile

There total 7 articles about (1R,2S,5S)-2-[(1R,3aS,4S,5S,7aR)-4-Hydroxy-7a-methyl-1-((Z)-(R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-5-yl]-5-methoxymethoxy-2-methyl-cyclohexanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,2S,5S)-5-Methoxymethoxy-2-methyl-2-[(1R,3aS,5S,7aR)-7a-methyl-4-oxo-1-((Z)-(R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-5-yl]-cyclohexanecarbonitrile (99598-73-9) → (1R,2S,5S)-2-[(1R,3aS,4S,5S,7aR)-4-Hydroxy-7a-methyl-1-((Z)-(R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-5-yl]-5-methoxymethoxy-2-methyl-cyclohexanecarbonitrile (99598-74-0)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; a) -78 deg C, b) RT;

Reference yield:

(1R,3aR,7aR)-7a-Methyl-1-((Z)-(R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-one (55812-80-1,55870-05-8,70144-73-9) → (1R,2S,5S)-2-[(1R,3aS,4S,5S,7aR)-4-Hydroxy-7a-methyl-1-((Z)-(R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-5-yl]-5-methoxymethoxy-2-methyl-cyclohexanecarbonitrile (99598-74-0)

Guidance literature:

Multi-step reaction with 7 steps

1: 75 percent / 5 h / 140 °C

2: DCC

4: 75 percent / toluene / 4 h / Ambient temperature

5: NaBH₄ / methanol / 0 °C

6: diisopropylethylamine / CH₂Cl₂ / 18 h / Heating

7: diisobutylaluminium hydride / tetrahydrofuran / a) -78 deg C, b) RT

With sodium tetrahydroborate; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; toluene;

Reference yield:

(1R,3aS,7aR)-7a-Methyl-4-oxo-1-((Z)-(R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-indene-5-carboxylic acid (99598-69-3) → (1R,2S,5S)-2-[(1R,3aS,4S,5S,7aR)-4-Hydroxy-7a-methyl-1-((Z)-(R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-5-yl]-5-methoxymethoxy-2-methyl-cyclohexanecarbonitrile (99598-74-0)

Guidance literature:

Multi-step reaction with 6 steps

1: DCC

3: 75 percent / toluene / 4 h / Ambient temperature

4: NaBH₄ / methanol / 0 °C

5: diisopropylethylamine / CH₂Cl₂ / 18 h / Heating

6: diisobutylaluminium hydride / tetrahydrofuran / a) -78 deg C, b) RT

With sodium tetrahydroborate; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; toluene;

upstream raw materials:

(1R,2S,5S)-5-Methoxymethoxy-2-methyl-2-[(1R,3aS,5S,7aR)-7a-methyl-4-oxo-1-((Z)-(R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-5-yl]-cyclohexanecarbonitrile

(1R,3aR,7aR)-7a-Methyl-1-((Z)-(R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-one

(1R,3aS,7aR)-7a-Methyl-4-oxo-1-((Z)-(R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-indene-5-carboxylic acid

(1R,3aS,7aR)-7a-Methyl-4-oxo-1-((Z)-(R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-indene-5-carboxylic acid 2-trimethylsilanyl-ethyl ester