Dioxyindolylalanine

Base Information

Chemical Name:Dioxyindolylalanine
CAS No.:184955-21-3
Molecular Formula:C₁₁H₁₂N₂O₄
Molecular Weight:236.227
Hs Code.:
UNII:KW5HNG2EAV
Mol file:184955-21-3.mol

Synonyms:dioxyindolylalanine;KW5HNG2EAV;(alphaS)-alpha-Amino-2,3-dihydro-3-hydroxy-2-oxo-1H-indole-3-propanoic acid;(2S)-2-Amino-3-((3RS)-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-3-yl)propanoic acid;UNII-KW5HNG2EAV;Dioxyindolylalanine [EP];Tryptophan impurity B [EP];SCHEMBL1520397;CHEBI:195384;MFCD21364455;DIOXYINDOLYLALANINE [EP IMPURITY];TRYPTOPHAN IMPURITY B [EP IMPURITY];N-ACETYLTRYPTOPHAN IMPURITY B [EP IMPURITY];(.ALPHA.S)-.ALPHA.-AMINO-2,3-DIHYDRO-3-HYDROXY-2-OXO-1H-INDOLE-3-PROPANOIC ACID;(S)-2-AMINO-3-((3RS)-3-HYDROXY-2-OXO-2,3-DIHYDRO-1H-INDOL-3-YL)PROPANOIC ACID;1H-INDOLE-3-PROPANOIC ACID, .ALPHA.-AMINO-2,3-DIHYDRO-3-HYDROXY-2-OXO-, (3(S))-;1H-Indole-3-propanoic acid, alpha-amino-2,3-dihydro-3-hydroxy-2-oxo-, (3(S))-;1H-Indole-3-propanoic acid, alpha-amino-2,3-dihydro-3-hydroxy-2-oxo-, (alphaS)-;1H-INDOLE-3-PROPANOIC ACID, .ALPHA.-AMINO-2,3-DIHYDRO-3-HYDROXY-2-OXO-, (.ALPHA.S)-

Suppliers and Price of Dioxyindolylalanine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Dioxindolyl-L-alanine(MixtureofDiastereomers)
50mg
$ 185.00

Medical Isotopes, Inc.
Dioxindolyl-L-alanine(MixtureofDiastereomers)
100 mg
$ 650.00

Total 11 raw suppliers

Chemical Property of Dioxyindolylalanine

Chemical Property:

Melting Point:>221°C (dec.)
Boiling Point:564.5±50.0 °C(Predicted)
PKA:2.18±0.10(Predicted)
Density:1.483±0.06 g/cm3(Predicted)
Storage Temp.:Refrigerator
Solubility.:Water (Slightly, Heated)
XLogP3:-2.6
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:236.07970687
Heavy Atom Count:17
Complexity:346

Purity/Quality:

99% ^*data from raw suppliers

Dioxindolyl-L-alanine(MixtureofDiastereomers) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(C(=O)N2)(CC(C(=O)O)N)O
Isomeric SMILES:C1=CC=C2C(=C1)C(C(=O)N2)(C[C@@H](C(=O)O)N)O
Uses Dioxindolyl-L-alanine is used in the synthesis of peptides containing 5-Hydroxytryptophan, Oxindolylalanine, N-Formylkynurenine and Kynurenine.

Technology Process of Dioxyindolylalanine

There total 25 articles about Dioxyindolylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 236094-74-9
2-amino-3-(2-oxoindolin-3-yl)propanoic acid

: 2922-83-0
L-kynurenine

: 184955-21-3
hydroxyoxoindolylalanine

Guidance literature:: With potassium chloride; oxygen; sodium hydroxide; In water; at 20 ℃; for 2h; pH=13;
DOI:10.1002/psc.1322

Reference yield: 3.0%

: 73-22-3,6912-86-3,54-12-6,153-94-6,63148-28-7,65556-72-1,27732-43-0,80206-30-0,27813-82-7
L-tryptophan

: 6536-35-2
oxindolyl-L-alanine

: 13081-15-7,76604-82-5,76604-83-6,128303-30-0,128357-72-2,184955-21-3
dioxindolyl-L-alanine

Guidance literature:: With hydrogenchloride; dimethyl sulfoxide; phenol; In acetic acid; for 5h; Ambient temperature;
DOI:10.1021/jo00303a027

Reference yield:

: 73-22-3,27732-43-0,80206-30-0,27813-82-7
L-Tryptophan

: 2922-83-0
L-kynurenine

: 184955-21-3
hydroxyoxoindolylalanine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; dimethyl sulfoxide / water; acetic acid / 5 h / 20 °C

2: potassium chloride; oxygen; sodium hydroxide / water / 2 h / 20 °C / pH 13

With hydrogenchloride; potassium chloride; oxygen; dimethyl sulfoxide; sodium hydroxide; In water; acetic acid;
DOI:10.1002/psc.1322