ethyl (2-(2-(4-(2-(4-(4-(2-(diethylamino)ethylamino)ethyl)phenylamino)-4-oxobutylamino)(2-oxoethyl)3,5-dimethypyrazol-1-yl)ethyl)amino)acetic acid

Base Information

Chemical Name:ethyl (2-(2-(4-(2-(4-(4-(2-(diethylamino)ethylamino)ethyl)phenylamino)-4-oxobutylamino)(2-oxoethyl)3,5-dimethypyrazol-1-yl)ethyl)amino)acetic acid
CAS No.:1259313-40-0
Molecular Formula:C₂₈H₄₃N₇O₅
Molecular Weight:557.693
Hs Code.:

ethyl (2-(2-(4-(2-(4-(4-(2-(diethylamino)ethylamino)ethyl)phenylamino)-4-oxobutylamino)(2-oxoethyl)3,5-dimethypyrazol-1-yl)ethyl)amino)acetic acid

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Chemical Property of ethyl (2-(2-(4-(2-(4-(4-(2-(diethylamino)ethylamino)ethyl)phenylamino)-4-oxobutylamino)(2-oxoethyl)3,5-dimethypyrazol-1-yl)ethyl)amino)acetic acid

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Technology Process of ethyl (2-(2-(4-(2-(4-(4-(2-(diethylamino)ethylamino)ethyl)phenylamino)-4-oxobutylamino)(2-oxoethyl)3,5-dimethypyrazol-1-yl)ethyl)amino)acetic acid

There total 9 articles about ethyl (2-(2-(4-(2-(4-(4-(2-(diethylamino)ethylamino)ethyl)phenylamino)-4-oxobutylamino)(2-oxoethyl)3,5-dimethypyrazol-1-yl)ethyl)amino)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1259313-32-0
ethyl 2-(2-(4-(2-(4-(4-(2-(diethylamino)ethylcarbamoyl)phenylamino)-4-oxobutylamino)-2-oxoethyl)-3,5-dimethylpyrazol-1-yl)ethylamino)acetate

: 1259313-40-0
ethyl (2-(2-(4-(2-(4-(4-(2-(diethylamino)ethylamino)ethyl)phenylamino)-4-oxobutylamino)(2-oxoethyl)3,5-dimethypyrazol-1-yl)ethyl)amino)acetic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; Reflux; Inert atmosphere;
DOI:10.1039/c0nj00256a

Reference yield:

: 1259313-27-3
benzyl 2-(1-(2-hydroxyethyl)-3,5-dimethylpyrazol-1-yl)acetate

: 1259313-40-0
ethyl (2-(2-(4-(2-(4-(4-(2-(diethylamino)ethylamino)ethyl)phenylamino)-4-oxobutylamino)(2-oxoethyl)3,5-dimethypyrazol-1-yl)ethyl)amino)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: triethylamine / acetonitrile / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / ethanol / 20 h / 20 °C / Inert atmosphere

4: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / acetonitrile / Reflux; Inert atmosphere

5: water; sodium hydroxide / tetrahydrofuran / Reflux; Inert atmosphere

With carbon tetrabromide; palladium 10% on activated carbon; water; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1039/c0nj00256a

Reference yield:

: 70598-04-8
benzyl 3-acetyl-4-oxopentanoate

: 1259313-40-0
ethyl (2-(2-(4-(2-(4-(4-(2-(diethylamino)ethylamino)ethyl)phenylamino)-4-oxobutylamino)(2-oxoethyl)3,5-dimethypyrazol-1-yl)ethyl)amino)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: ethanol / 0 - 20 °C / Inert atmosphere

2: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: triethylamine / acetonitrile / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / ethanol / 20 h / 20 °C / Inert atmosphere

5: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / acetonitrile / Reflux; Inert atmosphere

6: water; sodium hydroxide / tetrahydrofuran / Reflux; Inert atmosphere

With carbon tetrabromide; palladium 10% on activated carbon; water; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1039/c0nj00256a