Technology Process of (E)-2-<5-(p-Nitrophenyl)-7-phenyladamantyl> tosylate
There total 12 articles about (E)-2-<5-(p-Nitrophenyl)-7-phenyladamantyl> tosylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 77 percent / AlBr3 / 18 h / Ambient temperature
2: diethyl ether / 3 h / Ambient temperature
3: 1.) NaH, 2.) O2 / 1.) DMF, room temp., 8 h, 2.) 13 h
4: 100 percent / NaBH4 / propan-2-ol
5: 62.5 percent / tert-BuLi / tetrahydrofuran / Ambient temperature; 1.) 1 h, 2.) 3 h
6: nitric acid / nitromethane; acetic anhydride / 10 h / Ambient temperature
With
sodium tetrahydroborate; aluminum tri-bromide; tert.-butyl lithium; oxygen; nitric acid; sodium hydride;
In
tetrahydrofuran; diethyl ether; nitromethane; acetic anhydride; isopropyl alcohol;
DOI:10.1021/jo00080a012
- Guidance literature:
-
Multi-step reaction with 5 steps
1: diethyl ether / 3 h / Ambient temperature
2: 1.) NaH, 2.) O2 / 1.) DMF, room temp., 8 h, 2.) 13 h
3: 100 percent / NaBH4 / propan-2-ol
4: 62.5 percent / tert-BuLi / tetrahydrofuran / Ambient temperature; 1.) 1 h, 2.) 3 h
5: nitric acid / nitromethane; acetic anhydride / 10 h / Ambient temperature
With
sodium tetrahydroborate; tert.-butyl lithium; oxygen; nitric acid; sodium hydride;
In
tetrahydrofuran; diethyl ether; nitromethane; acetic anhydride; isopropyl alcohol;
DOI:10.1021/jo00080a012
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 77 percent / AlBr3 / 18 h / Ambient temperature
2: diethyl ether / 3 h / Ambient temperature
3: 1.) NaH, 2.) O2 / 1.) DMF, room temp., 8 h, 2.) 13 h
4: 100 percent / NaBH4 / propan-2-ol
5: 62.5 percent / tert-BuLi / tetrahydrofuran / Ambient temperature; 1.) 1 h, 2.) 3 h
6: nitric acid / nitromethane; acetic anhydride / 10 h / Ambient temperature
With
sodium tetrahydroborate; aluminum tri-bromide; tert.-butyl lithium; oxygen; nitric acid; sodium hydride;
In
tetrahydrofuran; diethyl ether; nitromethane; acetic anhydride; isopropyl alcohol;
DOI:10.1021/jo00080a012
